hasnat79/pubmed_breast_cancer · Datasets at Hugging Face

439

1

[Use of isotopes in the diagnosis of malignant breast tumors].

MEDLINE

Manual

NLM

The authors, with 67 Gallium, have obtained positive scintigraphy of the breast only in cases of carcinoma. Reliability of negative scintigraphy however is less good. Isotopic investigation of the bones is important in breast cancer and reveal early osseous metastasis.

Journal de gynecologie, obstetrique et biologie de la reproduction

0368-2315

Print

4 SUPPL 2

null

Print

1,975

null

109-16

G Destailleur (G); P Vernaillen (P); E Pluygers (E)

English Abstract (D004740); Journal Article (D016428)

Gallium Radioisotopes (Registry: 0, UI: D005710)

Breast Neoplasms (UI: D001943, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: Yes); metabolism (UI: Q000378, Major: No); Evaluation Studies as Topic (UI: D005069, Major: No); False Negative Reactions (UI: D005188, Major: No); Female (UI: D005260, Major: No); Gallium Radioisotopes (UI: D005710, Major: No); Humans (UI: D006801, Major: No); Hydrogen-Ion Concentration (UI: D006863, Major: No); Neoplasm Metastasis (UI: D009362, Major: No); Radiation Dosage (UI: D011829, Major: No); Radionuclide Imaging (UI: D011877, Major: Yes)

diagnosis (1); metabolism (0)|||||||||

0|0|0|0|0|0|0|0|0|1

null

1976-02-13

2015-11-19

pubmed: 1975-1-1; medline: 1975-1-1 0:1; entrez: 1975-1-1 0:0

pubmed: 439

Breast Neoplasms

['Neoplasm Metastasis']

2,274

1

Circulating levels of prolactin in human breast cancer.

MEDLINE

Manual

NLM

Serum prolactin concentrations were measured by radioimmunoassays in 98 patients with established carcinoma of breast, 12 patients with cystic mastitis and 10 patients with gynaecomastia and compared with that of age matched normal control women. The serum prolactin levels in the patients with breast cancer, gynaecomastia or cystic mastitis were observed to be similar to that in normal women. It was interesting to note that the levels of prolactin in the luteal phase of the cycle were higher than that in the early follicular phase in normal women.

British journal of cancer

0007-0920

Print

32

2

Print

1,975

Aug

null

160-7

N A Sheth (NA); K J Ranadive (KJ); J N Suraiya (JN); A R Sheth (AR)

Comparative Study (D003160); Journal Article (D016428)

Prolactin (Registry: 9002-62-4, UI: D011388); Luteinizing Hormone (Registry: 9002-67-9, UI: D007986)

Adult (UI: D000328, Major: No); Breast Neoplasms (UI: D001943, Major: No) - Qualifiers: blood (UI: Q000097, Major: Yes); etiology (UI: Q000209, Major: No); Female (UI: D005260, Major: No); Gynecomastia (UI: D006177, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Humans (UI: D006801, Major: No); Luteinizing Hormone (UI: D007986, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Male (UI: D008297, Major: No); Mastitis (UI: D008413, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Menopause (UI: D008593, Major: No); Menstruation (UI: D008598, Major: No); Middle Aged (UI: D008875, Major: No); Pregnancy (UI: D011247, Major: No); Prolactin (UI: D011388, Major: No) - Qualifiers: blood (UI: Q000097, Major: Yes); Time Factors (UI: D013997, Major: No)

|blood (1); etiology (0)||blood (0)||blood (0)||blood (0)|||||blood (1)|

0|0|0|0|0|0|0|0|0|0|0|0|0|0

null

1976-04-19

2019-05-15

pubmed: 1975-8-1; medline: 1975-8-1 0:1; entrez: 1975-8-1 0:0

pubmed: 14097352; pmc: PMC2024836; doi: 10.1038/bjc.1975.145

Breast Neoplasms

[]

2,401

1

Experience with a simple method for estrogen receptor assay in breast cancer.

MEDLINE

Manual

NLM

A simple procedure for the assay of specific estrogen receptors in breast cancer tissue is described. Estrogen receptors were detected in 74% of primary tumors, 71% of skin metastases and 63% of lymph node metastases. Postmenopausal patients and younger oophorectomized women had estrogen receptor-containing tumors more frequently, and at higher levels, than uncastrated, premenopausal, patients. The stability of estrogen receptors was not affected by the transportation of samples from distant hospitals, providing that they were kept frozen in Tris buffer, pH 8.0, at all times.

Clinica chimica acta; international journal of clinical chemistry

0009-8981

Print

67

2

Print

1,976

Mar

1

175-82

L Liskowski (L); D P Rose (DP)

Journal Article (D016428); Research Support, U.S. Gov't, P.H.S. (D013487)

Estrogens (Registry: 0, UI: D004967); Receptors, Cell Surface (Registry: 0, UI: D011956); Estradiol (Registry: 4TI98Z838E, UI: D004958)

Adult (UI: D000328, Major: No); Age Factors (UI: D000367, Major: No); Aged (UI: D000368, Major: No); Breast Neoplasms (UI: D001943, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: Yes); Castration (UI: D002369, Major: No); Estradiol (UI: D004958, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Estrogens (UI: D004967, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: Yes); Female (UI: D005260, Major: No); Humans (UI: D006801, Major: No); Hydrogen-Ion Concentration (UI: D006863, Major: No); Lymphatic Metastasis (UI: D008207, Major: No); Mastectomy (UI: D008408, Major: No); Menopause (UI: D008593, Major: No); Middle Aged (UI: D008875, Major: No); Neoplasm Metastasis (UI: D009362, Major: No); Receptors, Cell Surface (UI: D011956, Major: Yes); Skin Neoplasms (UI: D012878, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Specimen Handling (UI: D013048, Major: No); Temperature (UI: D013696, Major: No)

|||metabolism (1)||metabolism (0)|metabolism (1)||||||||||metabolism (0)||

0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|1|0|0|0

null

1976-04-27

2019-07-06

pubmed: 1976-3-1; medline: 1976-3-1 0:1; entrez: 1976-3-1 0:0

pubmed: 2401; pii: 0009-8981(76)90257-6; doi: 10.1016/0009-8981(76)90257-6

Breast Neoplasms

['Neoplasm Metastasis']

2,624

1

An optimized semi-automatic rate method for serum glutathione reductase activity and its application to patients with malignant disease.

MEDLINE

Manual

NLM

An improved and optimized method for serum glutathione reductase is described. The reference range for normal subjects is 47-79 IU/1. The method is more sensitive than conventional enzyme tests in the detection of malignant disease. It was not raised more frequently in patients with clinical evidence of metastases than in those clinically free of such metastases, and it did not seem to correlate with prognosis among those patients who failed to survive six months from the time the analysis was first conducted.

Journal of clinical pathology

0021-9746

Print

29

1

Print

1,976

Jan

null

73-7

A Delides (A); R J Spooner (RJ); D M Goldberg (DM); F E Neal (FE)

Journal Article (D016428)

Buffers (Registry: 0, UI: D002021); Enzyme Reactivators (Registry: 0, UI: D004793); NADP (Registry: 53-59-8, UI: D009249); Edetic Acid (Registry: 9G34HU7RV0, UI: D004492); Glutathione Reductase (Registry: EC 1.8.1.7, UI: D005980)

Aged (UI: D000368, Major: No); Buffers (UI: D002021, Major: No); Clinical Enzyme Tests (UI: D004796, Major: No) - Qualifiers: methods (UI: Q000379, Major: Yes); Edetic Acid (UI: D004492, Major: No); Enzyme Reactivators (UI: D004793, Major: No); Female (UI: D005260, Major: No); Glutathione Reductase (UI: D005980, Major: No) - Qualifiers: blood (UI: Q000097, Major: Yes); Humans (UI: D006801, Major: No); Male (UI: D008297, Major: No); Middle Aged (UI: D008875, Major: No); NADP (UI: D009249, Major: No); Neoplasm Metastasis (UI: D009362, Major: No); Neoplasms (UI: D009369, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: Yes); Prognosis (UI: D011379, Major: No)

||methods (1)||||blood (1)||||||diagnosis (1)|

0|0|0|0|0|0|0|0|0|0|0|0|0|0

null

1976-04-29

2019-05-01

pubmed: 1976-1-1; medline: 1976-1-1 0:1; entrez: 1976-1-1 0:0

pubmed: 4834006; pmc: PMC475950; doi: 10.1136/jcp.29.1.73

Breast Neoplasms

['Neoplasm Metastasis']

3,117

1

Cancer of the undescended or maldescended testis.

MEDLINE

Manual

NLM

An analysis of 45 cryptorchids (by history or examination) with a testicular cancer treated at Memorial Hospital, between 1934 and 1973, is presented. Twenty-five patients had the cryptorchid state repaired at ages four to 27 years, either spontaneously or by orchiopexy or hormonal therapy. Ipsilateral (24) or contralateral (one) intrascrotal testis tumors developed four to 47 years later. Twenty cryptorchid patients presented with ipsilateral inguinal (eleven), abdominal (seven), or contralateral intrascrotal (two) tumors. There were 18 pure seminomas, 17 embryonal carcinomas, nine teratocarcinomas, and one reticulum cell sarcoma. Five year survival rates as estimated by the product-limit method were 60% for the unrepaired cases and 41% for the repaired cases. The survival seems to follow histologic type and anatomical stage, whether the testis is within the scrotum or not. Five year survival similarly estimated was 78% in the seminomas and 29% in the other tumors. Twelve of thirteen survivors (including nine with seminoma) received postoperative irradiation to the regional lymphatics and eleven were without recurrent tumor for periods ranging from six to 28 years.

AJR. American journal of roentgenology

0361-803X

Print

126

2

Print

1,976

Feb

null

302-12

M A Batata (MA); W F Whitmore (WF); B S Hilaris (BS); N Tokita (N); H Grabstald (H)

Journal Article (D016428)

null

Adolescent (UI: D000293, Major: No); Adult (UI: D000328, Major: No); Child (UI: D002648, Major: No); Child, Preschool (UI: D002675, Major: No); Cryptorchidism (UI: D003456, Major: No) - Qualifiers: complications (UI: Q000150, Major: Yes); Dysgerminoma (UI: D004407, Major: No) - Qualifiers: complications (UI: Q000150, Major: Yes); diagnosis (UI: Q000175, Major: No); pathology (UI: Q000473, Major: No); therapy (UI: Q000628, Major: No); Follow-Up Studies (UI: D005500, Major: No); Humans (UI: D006801, Major: No); Lymphoma, Large B-Cell, Diffuse (UI: D016403, Major: No) - Qualifiers: complications (UI: Q000150, Major: Yes); diagnosis (UI: Q000175, Major: No); pathology (UI: Q000473, Major: No); therapy (UI: Q000628, Major: No); Male (UI: D008297, Major: No); Middle Aged (UI: D008875, Major: No); Neoplasm Metastasis (UI: D009362, Major: No); Teratoma (UI: D013724, Major: No) - Qualifiers: complications (UI: Q000150, Major: Yes); diagnosis (UI: Q000175, Major: No); pathology (UI: Q000473, Major: No); therapy (UI: Q000628, Major: No); Testicular Neoplasms (UI: D013736, Major: No) - Qualifiers: complications (UI: Q000150, Major: Yes); diagnosis (UI: Q000175, Major: No); pathology (UI: Q000473, Major: No); therapy (UI: Q000628, Major: No)

||||complications (1)|complications (1); diagnosis (0); pathology (0); therapy (0)|||complications (1); diagnosis (0); pathology (0); therapy (0)||||complications (1); diagnosis (0); pathology (0); therapy (0)|complications (1); diagnosis (0); pathology (0); therapy (0)

0|0|0|0|0|0|0|0|0|0|0|0|0|0

null

1976-04-30

2009-10-27

pubmed: 1976-2-1; medline: 2001-3-28 10:1; entrez: 1976-2-1 0:0

pubmed: 3117; doi: 10.2214/ajr.126.2.302

Breast Neoplasms

['Neoplasm Metastasis']

3,291

1

[Effect of intratumoral injection of bacterial and viral neuraminidase in rats].

MEDLINE

Manual

NLM

We studied the effect of neuraminidase injection in rat's tumor at different doses: 5,10,50,100, 500 U and we concluded that: There was no difference between the rats treated with 5,10,50 U and the controls. The y died 3 weeks after the injection. But the rats treated by 100 at 500 U of NA died quickley, in the week, of long metastases.

Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles

null

281

20

Print

1,975

Nov

17

1545-7

P Binder (P); L Perrot (L); Y Beaudry (Y); C Bottex (C); R Fontanges (R)

English Abstract (D004740); Journal Article (D016428)

Neuraminidase (Registry: EC 3.2.1.18, UI: D009439)

Animals (UI: D000818, Major: No); Cloaca (UI: D002988, Major: Yes); Influenza A virus (UI: D009980, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: No); Lung Neoplasms (UI: D008175, Major: No) - Qualifiers: etiology (UI: Q000209, Major: Yes); Malpighian Tubules (UI: D008317, Major: Yes); Neoplasm Metastasis (UI: D009362, Major: No); Neoplasms, Experimental (UI: D009374, Major: Yes); Neuraminidase (UI: D009439, Major: No) - Qualifiers: pharmacology (UI: Q000494, Major: Yes); Rats (UI: D051381, Major: No); Streptococcus pneumoniae (UI: D013296, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: No)

||enzymology (0)|etiology (1)||||pharmacology (1)||enzymology (0)

0|1|0|0|1|0|1|0|0|0

null

1976-06-02

2019-10-21

pubmed: 1975-11-17; medline: 1975-11-17 0:1; entrez: 1975-11-17 0:0

pubmed: 3291

Breast Neoplasms

['Neoplasm Metastasis']

3,632

1

Sudden hemorrhage in metastatic thyroid carcinoma of the brain during treatment with iodine-131.

MEDLINE

Manual

NLM

A patient with papillary--follicular carcinoma of the thyroid, with metastases to the lungs, skeleton, and brain was treated 5 weeks after thyroidectomy with 135 mCi of 131I. Although preliminary studies with 1 mCi had not shown any iodine uptake by the brain metastasis, this lesion showed intense concentration at the time of the larger therapeutic dose. Four days later, acute hemorrhage of the tumor occurred, requiring surgical removal. Although 131I therapy would seem an unlikely cause of acute necrosis and hemorrhage in these lesions, the association of therapeutic radioiodine and hemorrhage is interesting. Since recent reports suggest that brain metastasis may be somewhat more common than previously suspected, we suggest that brain imaging be included in the workup prior to radioiodine therapy of patients with advanced metastatic disease or neurologic symptoms.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

0161-5505

Print

17

4

Print

1,976

Apr

null

307-9

D L Holmquest (DL); P Lake (P)

Case Reports (D002363); Journal Article (D016428)

Iodine Radioisotopes (Registry: 0, UI: D007457)

Adenocarcinoma (UI: D000230, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); Brain Neoplasms (UI: D001932, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: Yes); Cerebral Hemorrhage (UI: D002543, Major: No) - Qualifiers: etiology (UI: Q000209, Major: Yes); Humans (UI: D006801, Major: No); Iodine Radioisotopes (UI: D007457, Major: No) - Qualifiers: adverse effects (UI: Q000009, Major: Yes); Male (UI: D008297, Major: No); Middle Aged (UI: D008875, Major: No); Neoplasm Metastasis (UI: D009362, Major: No); Radionuclide Imaging (UI: D011877, Major: No) - Qualifiers: adverse effects (UI: Q000009, Major: Yes); Thyroid Neoplasms (UI: D013964, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: Yes)

diagnosis (0)|diagnosis (1)|etiology (1)||adverse effects (1)||||adverse effects (1)|diagnosis (1)

0|0|0|0|0|0|0|0|0|0

null

1976-05-25

2022-03-31

pubmed: 1976-4-1; medline: 1976-4-1 0:1; entrez: 1976-4-1 0:0

pubmed: 3632

Breast Neoplasms

['Neoplasm Metastasis']

3,660

1

Biochemical properties of cyclic nucleotide phosphodiesterase in metastasizing and nonmetastasizing rat mammary carcinomas.

MEDLINE

Manual

NLM

The biochemical properties of cyclic nucleotide phosphodiesterases in a nonmetastasizing and a spontaneously metastasizing rat mammary carcinoma were compared. The phosphooiesterases in both tumors had a pH optimum of around 8.0 and preferentially hydrolysed cyclic purine nucleotides. The rate of hydrolysis of purine nucleotides in the nonmetastasizing tumor was two times higher than in the metastasizing tumor, but the rate of pyrimidine nucleotide hydrolysis was equal in both tumors. Theophylline, caffeine, and D,L-4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone (Ro20-1724) inhibited the enzyme activity in both tumors; the percent inhibition was the same by each inhibitor. The cyclic nucleotie phosphodiesterase activity in either tumor was stimulated by Mg++, Mn++, and Co++ and suppressed by Ca++, Zn,++, and Ni++. EDTA inhibited the activity below the basal level (activity in the absence of added cation), an this inhibition could be recovered up to the basal level by an equimolar quantity of either Mn++ or Mg++. Further stimulation of the enzyme activity with increasing concentrations of divalent cations was observed only with Mn++. Similar effects were observe with ethylene glycol bis(beta-aminoethyl ether)-tn,n-tetraacetic acid. The stimulatory cations affected both the low and high Michaelis constant (tkm) enzymes in these tumors by increasing the maximum velocity. In the low Km enzyme, the Km was also slightly increased. Neither guanosine 3',5'-cyclic monophosphate nor adenosine 3',5'-cyclic monophosphate had any effect on the hydrolysis of the other at physiologic levels.

Journal of the National Cancer Institute

0027-8874

Print

56

1

Print

1,976

Jan

null

105-10

S K Chatterjee (SK); U Kim (U)

Comparative Study (D003160); Journal Article (D016428); Research Support, U.S. Gov't, P.H.S. (D013487)

Purine Nucleotides (Registry: 0, UI: D011685); Pyrimidine Nucleotides (Registry: 0, UI: D011742); 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone (Registry: 29925-17-5, UI: D012368); Cobalt (Registry: 3G0H8C9362, UI: D003035); Caffeine (Registry: 3G6A5W338E, UI: D002110); Manganese (Registry: 42Z2K6ZL8P, UI: D008345); Egtazic Acid (Registry: 526U7A2651, UI: D004533); Nickel (Registry: 7OV03QG267, UI: D009532); Edetic Acid (Registry: 9G34HU7RV0, UI: D004492); Theophylline (Registry: C137DTR5RG, UI: D013806); Cyclic AMP (Registry: E0399OZS9N, UI: D000242); Cyclic GMP (Registry: H2D2X058MU, UI: D006152); Magnesium (Registry: I38ZP9992A, UI: D008274); Zinc (Registry: J41CSQ7QDS, UI: D015032); Calcium (Registry: SY7Q814VUP, UI: D002118)

4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone (UI: D012368, Major: No) - Qualifiers: pharmacology (UI: Q000494, Major: No); Animals (UI: D000818, Major: No); Caffeine (UI: D002110, Major: No) - Qualifiers: pharmacology (UI: Q000494, Major: No); Calcium (UI: D002118, Major: No); Cobalt (UI: D003035, Major: No); Cyclic AMP (UI: D000242, Major: No) - Qualifiers: pharmacology (UI: Q000494, Major: No); Cyclic GMP (UI: D006152, Major: No) - Qualifiers: pharmacology (UI: Q000494, Major: No); Depression, Chemical (UI: D003864, Major: No); Edetic Acid (UI: D004492, Major: No) - Qualifiers: pharmacology (UI: Q000494, Major: No); Egtazic Acid (UI: D004533, Major: No) - Qualifiers: pharmacology (UI: Q000494, Major: No); Hydrogen-Ion Concentration (UI: D006863, Major: No); Magnesium (UI: D008274, Major: No); Manganese (UI: D008345, Major: No); Neoplasm Metastasis (UI: D009362, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: Yes); Nickel (UI: D009532, Major: No); Purine Nucleotides (UI: D011685, Major: No); Pyrimidine Nucleotides (UI: D011742, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Rats (UI: D051381, Major: No); Theophylline (UI: D013806, Major: No) - Qualifiers: pharmacology (UI: Q000494, Major: No); Zinc (UI: D015032, Major: No)

pharmacology (0)||pharmacology (0)|||pharmacology (0)|pharmacology (0)||pharmacology (0)|pharmacology (0)||||enzymology (1)|||metabolism (0)||pharmacology (0)|

0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0

null

1976-05-10

2019-05-09

pubmed: 1976-1-1; medline: 1976-1-1 0:1; entrez: 1976-1-1 0:0

pubmed: 3660; doi: 10.1093/jnci/56.1.105

Breast Neoplasms

['Neoplasm Metastasis']

4,218

1

Liver metastases found by follow-up of patients operated on for colorectal cancer.

MEDLINE

Manual

NLM

One hundred and twenty-six patients earlier operated on for colorectal cancer were followed-up once yearly with serum screening tests. The activities of alkaline phosphatase (AP) and gammaglutamyltranspeptidase (GT) were recorded. 58 patients had positive tests. The majority of the patients with liver metastases (20/21) was possible to encircle with these simple serum tests. 38 of the 58 ""screening positive patients"" were further investigated with celiac angiography and/or liver scintigraphy and liver metastases were very suspect in 29 of these patients. 18 of them were laparotomized and the suspicion was verified in 8.7 of these patients could be subjected to surgery against their liver tumours and 2 of them have then survived more than 2 years. The authors suggest a follow-up system with shorter interval between the examinations.

Cancer

0008-543X

Print

37

3

Print

1,976

Mar

null

1454-7

O Almersjö (O); S Bengmark (S); L Hafström (L)

Case Reports (D002363); Journal Article (D016428)

gamma-Glutamyltransferase (Registry: EC 2.3.2.2, UI: D005723); Alkaline Phosphatase (Registry: EC 3.1.3.1, UI: D000469)

Adult (UI: D000328, Major: No); Aged (UI: D000368, Major: No); Alkaline Phosphatase (UI: D000469, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Colonic Neoplasms (UI: D003110, Major: No) - Qualifiers: pathology (UI: Q000473, Major: Yes); surgery (UI: Q000601, Major: No); Humans (UI: D006801, Major: No); Laparotomy (UI: D007813, Major: No); Liver Neoplasms (UI: D008113, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); pathology (UI: Q000473, Major: Yes); therapy (UI: Q000628, Major: No); Middle Aged (UI: D008875, Major: No); Neoplasm Metastasis (UI: D009362, Major: No); Rectal Neoplasms (UI: D012004, Major: No) - Qualifiers: pathology (UI: Q000473, Major: Yes); surgery (UI: Q000601, Major: No); gamma-Glutamyltransferase (UI: D005723, Major: No) - Qualifiers: blood (UI: Q000097, Major: No)

||blood (0)|pathology (1); surgery (0)|||diagnosis (0); pathology (1); therapy (0)|||pathology (1); surgery (0)|blood (0)

0|0|0|0|0|0|0|0|0|0|0

null

1976-07-06

2019-06-19

pubmed: 1976-3-1; medline: 1976-3-1 0:1; entrez: 1976-3-1 0:0

pubmed: 4218; doi: 10.1002/1097-0142(197603)37:3<1454::aid-cncr2820370329>3.0.co;2-d

Breast Neoplasms

['Neoplasm Metastasis']

4,219

1

Carcinoembryonic antigen and phosphohexose isomerase, gammaglutamyl transpeptidase and lactate dehydorgenase levels in patients with and without liver metastases.

MEDLINE

Manual

NLM

Plasma carcinoembryonic antigen (CEA) and serum enzyme levels of phosphohexose isomerase (PHI), gamma-glutamyl transpeptidase (psi-GTP), and lactate dehydrogenase (LDH) were measured in 147 patients with malignancy. Levels were higher in patients (particularly with G.I., breast and lung cancers) than in normals or in patients with cancer in clinical remission. Elevations of CEA and of all three enzymes in blood were most frequent in patients with hepatic metastases. CEA elevations correlated directly with PHI levels. Seventy-eight percent of patients with metastatic G.I. cancer could be identified by CEA (greater than 5 ng/ml) alone, as well as 38% with breast cancer and 85% with lung cancer; but only 17% of other cancers could be identified by CEA alone. CEA or one or more enzymes was elevated in 64% of metastatic breast cancer patients, 92% of lung cancer and 41% of other cancers, but enzyme measurement did not increase identification of G.I. cancer over that achieved by CEA alone. These findings suggest that circulating levels of CEA, PHI, psi-GTP and LDH may reflect a direct contribution from the malignant tissue and/or liver malfunction secondary to liver replacement.

Cancer

0008-543X

Print

37

4

Print

1,976

Apr

null

1800-7

D Munjal (D); P L Chawla (PL); J J Lokich (JJ); N Zamcheck (N)

Case Reports (D002363); Journal Article (D016428); Research Support, U.S. Gov't, P.H.S. (D013487)

Carcinoembryonic Antigen (Registry: 0, UI: D002272); L-Lactate Dehydrogenase (Registry: EC 1.1.1.27, UI: D007770); gamma-Glutamyltransferase (Registry: EC 2.3.2.2, UI: D005723); Glucose-6-Phosphate Isomerase (Registry: EC 5.3.1.9, UI: D005956)

Breast Neoplasms (UI: D001943, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Carcinoembryonic Antigen (UI: D002272, Major: Yes) - Qualifiers: analysis (UI: Q000032, Major: No); Gastrointestinal Neoplasms (UI: D005770, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Glucose-6-Phosphate Isomerase (UI: D005956, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Humans (UI: D006801, Major: No); L-Lactate Dehydrogenase (UI: D007770, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Liver Neoplasms (UI: D008113, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: No); immunology (UI: Q000276, Major: No); metabolism (UI: Q000378, Major: Yes); Lung Neoplasms (UI: D008175, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Neoplasm Metastasis (UI: D009362, Major: No); Neoplasms (UI: D009369, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: Yes); gamma-Glutamyltransferase (UI: D005723, Major: No) - Qualifiers: blood (UI: Q000097, Major: No)

metabolism (0)|analysis (0)|metabolism (0)|blood (0)||blood (0)|enzymology (0); immunology (0); metabolism (1)|metabolism (0)||metabolism (1)|blood (0)

0|1|0|0|0|0|0|0|0|0|0

null

1976-07-06

2019-06-19

pubmed: 1976-4-1; medline: 1976-4-1 0:1; entrez: 1976-4-1 0:0

pubmed: 4219; doi: 10.1002/1097-0142(197604)37:4<1800::aid-cncr2820370426>3.0.co;2-k

Breast Neoplasms

['Neoplasm Metastasis']

8,466

1

Gallium-67 citrate scintiscanning in testicular neoplasia.

MEDLINE

Manual

NLM

Gallium-67 citrate has been used to evaluate 19 patients with malignant tumors of the testes. Five patients with abnormal uptake of the radiotracer in the abdomen proved to have other evidence confirming metastatic spread to this site. Eight patients, with normal scan findings, surgery and lymphangiorgraphy, provided no conflicting evidence of disease although one of these patients has subsequently developed increased urinary gonadotrophin concentrations. Surgery caused an abnormal scan and such patients were excluded from the analysis pointing to the need for preoperative evaluation. The technique of 67-gallium scintigraphy appears of value in assessing the intra-abdominal spread of malignant tumors of the testes.

Journal of the Canadian Association of Radiologists

0008-2902

Print

27

2

Print

1,976

Jun

null

84-8

F I Jackson (FI); H C Dierich (HC); B C Lentle (BC)

Case Reports (D002363); Journal Article (D016428)

Citrates (Registry: 0, UI: D002951); Gallium Radioisotopes (Registry: 0, UI: D005710)

Adolescent (UI: D000293, Major: No); Adult (UI: D000328, Major: No); Citrates (UI: D002951, Major: No); Cryptorchidism (UI: D003456, Major: No) - Qualifiers: complications (UI: Q000150, Major: No); Dysgerminoma (UI: D004407, Major: No) - Qualifiers: complications (UI: Q000150, Major: No); diagnosis (UI: Q000175, Major: Yes); Gallium Radioisotopes (UI: D005710, Major: Yes); Humans (UI: D006801, Major: No); Male (UI: D008297, Major: No); Middle Aged (UI: D008875, Major: No); Neoplasm Metastasis (UI: D009362, Major: No); Radionuclide Imaging (UI: D011877, Major: Yes); Teratoma (UI: D013724, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); Testicular Neoplasms (UI: D013736, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: Yes)

|||complications (0)|complications (0); diagnosis (1)|||||||diagnosis (0)|diagnosis (1)

0|0|0|0|0|1|0|0|0|0|1|0|0

null

1976-11-01

2015-11-19

pubmed: 1976-6-1; medline: 1976-6-1 0:1; entrez: 1976-6-1 0:0

pubmed: 8466

Breast Neoplasms

['Neoplasm Metastasis']

9,001

1

Plasma activities of lysosomal enzymes after hepatic dearterialization in man.

MEDLINE

Manual

NLM

Six patients with liver metastases from carcinoid or colon carcinoma underwent hepatic derterialization. This operation, known to cause both tumor necrosis and liver cell damage, caused considerable increases of several lysosomal acid hydrolases in the circulation. Thus, beta-glucosidase showed a small temporary increase during the operation, followed by a slower but higher reaction reaching a maximum 12 to 36 hours postoperatively. Similar reactions were noted for beta-glucuronidase, acid phosphatase, beta-galactosidase, arylsuphatase A, and N-acetyl-beta-glucosaminidase while no reactions were found for cathepsin D. Very high enzyme levels occurred in a patient dying from bleeding complications in the postoperative period.

American journal of surgery

0002-9610

Print

132

3

Print

1,976

Sep

null

363-7

S Bengmark (S); B Böjesson (B); P E Fredlund (PE); J O Vang (JO)

Journal Article (D016428)

Aspartate Aminotransferases (Registry: EC 2.6.1.1, UI: D001219); Hydrolases (Registry: EC 3.-, UI: D006867); Acid Phosphatase (Registry: EC 3.1.3.2, UI: D000135); Cerebroside-Sulfatase (Registry: EC 3.1.6.8, UI: D002553); Glucosidases (Registry: EC 3.2.1.-, UI: D005959); Glucuronidase (Registry: EC 3.2.1.31, UI: D005966); Cathepsins (Registry: EC 3.4.-, UI: D002403)

Acid Phosphatase (UI: D000135, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Aspartate Aminotransferases (UI: D001219, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Carcinoid Tumor (UI: D002276, Major: No) - Qualifiers: surgery (UI: Q000601, Major: No); Cathepsins (UI: D002403, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Cerebroside-Sulfatase (UI: D002553, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Glucosidases (UI: D005959, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Glucuronidase (UI: D005966, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Hepatic Artery (UI: D006499, Major: No) - Qualifiers: surgery (UI: Q000601, Major: Yes); Humans (UI: D006801, Major: No); Hydrolases (UI: D006867, Major: No) - Qualifiers: blood (UI: Q000097, Major: Yes); Ligation (UI: D008026, Major: No); Liver (UI: D008099, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: No); Liver Neoplasms (UI: D008113, Major: No) - Qualifiers: surgery (UI: Q000601, Major: No); Neoplasm Metastasis (UI: D009362, Major: No)

blood (0)|blood (0)|surgery (0)|blood (0)|blood (0)|blood (0)|blood (0)|surgery (1)||blood (1)||enzymology (0)|surgery (0)|

0|0|0|0|0|0|0|0|0|0|0|0|0|0

null

1976-11-01

2019-06-27

pubmed: 1976-9-1; medline: 1976-9-1 0:1; entrez: 1976-9-1 0:0

pubmed: 9001; pii: 0002-9610(76)90394-9; doi: 10.1016/0002-9610(76)90394-9

Breast Neoplasms

['Neoplasm Metastasis']

10,716

1

A new pattern of multiple endocrine adenomatosis: chemodectoma, bronchial carcinoid, GH-producing pituitary adenoma, and hyperplasia of the parathyroid glands, and antral and duodenal gastrin cells.

MEDLINE

Manual

NLM

A female patient was found to have a chemodectoma, a GH-producing pituitary tumour and a bronchial carcinoid combined with hyperplasia of the parathyroids and of antral and duodenal gastrin cells. This combination of endocrine tumours and hyperplasias does not fit with the two multiple endocrine adenomatosis syndromes recognized at present. The case stresses the importance of scanning the patient for other endocrine tumours, once one has been diagnosed.

Acta medica Scandinavica

0001-6101

Print

200

4

Print

1,976

null

321-26

B Berg (B); A Biörklund (A); L Grimelius (L); S Ingemansson (S); L I Larsson (LI); U Stenram (U); M Akerman (M)

Case Reports (D002363); Journal Article (D016428)

null

Adenoma (UI: D000236, Major: Yes) - Qualifiers: pathology (UI: Q000473, Major: No); Adult (UI: D000328, Major: No); Bronchial Neoplasms (UI: D001984, Major: No) - Qualifiers: pathology (UI: Q000473, Major: No); Carcinoma, Adenoid Cystic (UI: D003528, Major: Yes) - Qualifiers: pathology (UI: Q000473, Major: No); Female (UI: D005260, Major: No); Gastric Mucosa (UI: D005753, Major: No) - Qualifiers: pathology (UI: Q000473, Major: No); Head and Neck Neoplasms (UI: D006258, Major: No) - Qualifiers: pathology (UI: Q000473, Major: No); Humans (UI: D006801, Major: No); Hyperplasia (UI: D006965, Major: No); Intestinal Mucosa (UI: D007413, Major: No) - Qualifiers: pathology (UI: Q000473, Major: No); Mediastinal Neoplasms (UI: D008479, Major: No) - Qualifiers: pathology (UI: Q000473, Major: No); Multiple Endocrine Neoplasia (UI: D009377, Major: Yes) - Qualifiers: pathology (UI: Q000473, Major: No); Neoplasm Metastasis (UI: D009362, Major: No); Paraganglioma, Extra-Adrenal (UI: D010236, Major: Yes) - Qualifiers: pathology (UI: Q000473, Major: No); Parathyroid Glands (UI: D010280, Major: No) - Qualifiers: pathology (UI: Q000473, Major: No); Pituitary Neoplasms (UI: D010911, Major: Yes) - Qualifiers: pathology (UI: Q000473, Major: No)

pathology (0)||pathology (0)|pathology (0)||pathology (0)|pathology (0)|||pathology (0)|pathology (0)|pathology (0)||pathology (0)|pathology (0)|pathology (0)

1|0|0|1|0|0|0|0|0|0|0|1|0|1|0|1

null

1976-12-23

2004-11-17

pubmed: 1976-1-1; medline: 1976-1-1 0:1; entrez: 1976-1-1 0:0

pubmed: 10716

Breast Neoplasms

['Neoplasm Metastasis']

11,043

1

Microdose mammography.

MEDLINE

Manual

NLM

Tens of thousands of mammograms are performed daily in the United States. Accumulated radiation biologic data suggest that approximately 90-rad is the level of radition to the breast above which the incidence of cancer may be increase. A microdose system of roentgenography is described that provides better images at one-third to one-fifth the exposure of the commonly used low-dose system and about one-eight to one-tenth the dose of Xeromammography. This system should allow for repeated x-ray study in a patient as required, without exceeding the critical level.

Cancer

0008-543X

Print

38

5

Print

1,976

Nov

null

1947-51

M B Hermel (MB); M G Murdock (MG)

Journal Article (D016428); Review (D016454)

null

Breast Neoplasms (UI: D001943, Major: No) - Qualifiers: diagnostic imaging (UI: Q000000981, Major: No); Female (UI: D005260, Major: No); Humans (UI: D006801, Major: No); Mammography (UI: D008327, Major: Yes) - Qualifiers: adverse effects (UI: Q000009, Major: No); methods (UI: Q000379, Major: No); Maximum Allowable Concentration (UI: D008452, Major: No); Neoplasms, Radiation-Induced (UI: D009381, Major: No) - Qualifiers: etiology (UI: Q000209, Major: No); Radiation Dosage (UI: D011829, Major: No); Technology, Radiologic (UI: D013679, Major: No)

diagnostic imaging (0)|||adverse effects (0); methods (0)||etiology (0)||

0|0|0|1|0|0|0|0

null

1977-01-25

2019-06-19

pubmed: 1976-11-1; medline: 1976-11-1 0:1; entrez: 1976-11-1 0:0

pubmed: 11043; doi: 10.1002/1097-0142(197611)38:5<1947::aid-cncr2820380515>3.0.co;2-x

Breast Neoplasms

[]

11,152

1

Effect of size of Morris hepatoma 5123D on gamma-glutamyltranspeptidase activity in serum and urine.

MEDLINE

Manual

NLM

Close correlation between the size of Morris hepatoma 5123D implanted in the hind limb of rat and serum gamm-glutamyltranspeptidase activity was found. The tumour implanted in both hind legs of the rat resulted in about twofold increase of the serum enzyme activity. The growth of the hepatoma resulted also in a significant increase in the enzyme activity in urine of the tumour-bearing rats. After surgical removal of the leg with hepatoma a rapid decrease in the enzyme activity in both the studied body fluids and its subsequent renewed increase associated with formation of pulmonary metastases were observed. Partial hepatectomy and pancreatectomy were without effect on the serum gamma-glutamyltranspeptidase activity.

Folia histochemica et cytochemica

0015-5586

Print

14

3

Print

1,976

null

181-7

W Albert (W)

Journal Article (D016428)

gamma-Glutamyltransferase (Registry: EC 2.3.2.2, UI: D005723)

Age Factors (UI: D000367, Major: No); Animals (UI: D000818, Major: No); Carcinoma, Hepatocellular (UI: D006528, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: No); pathology (UI: Q000473, Major: Yes); Hepatectomy (UI: D006498, Major: No); Liver Neoplasms (UI: D008113, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: No); pathology (UI: Q000473, Major: Yes); Male (UI: D008297, Major: No); Neoplasm Metastasis (UI: D009362, Major: No); Neoplasm Transplantation (UI: D009368, Major: No); Pancreatectomy (UI: D010180, Major: No); Rats (UI: D051381, Major: No); gamma-Glutamyltransferase (UI: D005723, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); metabolism (UI: Q000378, Major: Yes); urine (UI: Q000652, Major: No)

||enzymology (0); pathology (1)||enzymology (0); pathology (1)||||||blood (0); metabolism (1); urine (0)

0|0|0|0|0|0|0|0|0|0|0

null

1977-01-25

2003-11-14

pubmed: 1976-1-1; medline: 1976-1-1 0:1; entrez: 1976-1-1 0:0

pubmed: 11152

Breast Neoplasms

['Neoplasm Metastasis']

11,886

1

Isoferritin composition of tissues and serum in human cancers.

MEDLINE

Manual

NLM

A highly sensitive technique for isoferritin detection using 125I-labeled monospecific anti-human liver ferritin antibody for the identification of isoferritins after the analysis of small quantities of ferritin by isoelectric focusing in polyacryl-amide gels was applied to the study of renal, pancreatic, and colonic carcinomas. In all tumors studied, the isoferritin composition differed from that of the corresponding normal tissue; major isoferritins with pl more basic than those of the normal tissues were consistently detected. Composition of purified ferritin from metastases closely resembled the isoferritin composition of the primary tumors. Examination of the serum isoferritin profiles of four patients with cancers did not reveal the presence of any tumor-specific changes in isoferritins. It is suggested that the abnormality in tissue ferritins in the three human cancers studied is the synthesis of major isoferritins in the more basic range, rather than the appearance of tumor-specific isoferritins in the more acidic range.

Cancer research

0008-5472

Print

36

12

Print

1,976

Dec

null

4486-90

J W Halliday (JW); L V McKeering (LV); L W Powell (LW)

Journal Article (D016428)

Ferritins (Registry: 9007-73-2, UI: D005293)

Colonic Neoplasms (UI: D003110, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Female (UI: D005260, Major: No); Ferritins (UI: D005293, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); immunology (UI: Q000276, Major: No); metabolism (UI: Q000378, Major: Yes); Humans (UI: D006801, Major: No); Hydrogen-Ion Concentration (UI: D006863, Major: No); Immunoassay (UI: D007118, Major: No) - Qualifiers: methods (UI: Q000379, Major: No); Isoelectric Point (UI: D007526, Major: No); Kidney Neoplasms (UI: D007680, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Liver Neoplasms (UI: D008113, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Male (UI: D008297, Major: No); Neoplasm Metastasis (UI: D009362, Major: No); Neoplasms (UI: D009369, Major: No) - Qualifiers: analysis (UI: Q000032, Major: No); metabolism (UI: Q000378, Major: Yes); Pancreatic Neoplasms (UI: D010190, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No)

metabolism (0)||blood (0); immunology (0); metabolism (1)|||methods (0)||metabolism (0)|metabolism (0)|||analysis (0); metabolism (1)|metabolism (0)

0|0|0|0|0|0|0|0|0|0|0|0|0

null

1977-02-16

2006-11-15

pubmed: 1976-12-1; medline: 1976-12-1 0:1; entrez: 1976-12-1 0:0

pubmed: 11886

Breast Neoplasms

['Neoplasm Metastasis']

12,893

1

Measurement of estradiol receptors in human breast tumors by polyacrylamide gel electrophoresis.

MEDLINE

Manual

NLM

1. Specific estradiol receptors in cytosols from human breast tumors were measured by discontinuous polyacrylamide gel electrophoresis. 2. Binding of estradiol to contaminating sex hormone binding globulin was clearly separated from that due to the specific receptor. 3. The amount of estradiol bound by the receptor was linear with respect to the amount of protein added to gel. 4. The estradiol receptor peak of radioactivity showed saturability and specificity characteristic of an intracellular receptor. 5. The results show that polyacrylamide gel electrophoresis can be used to quantitate specific estradiol receptors in the presence of other high affinity binding components.

Clinica chimica acta; international journal of clinical chemistry

0009-8981

Print

74

2

Print

1,977

Jan

17

161-6

M J Duffy (MJ); G J Duffy (GJ)

Journal Article (D016428)

Neoplasm Proteins (Registry: 0, UI: D009363); Receptors, Estrogen (Registry: 0, UI: D011960); Steroids (Registry: 0, UI: D013256); Estradiol (Registry: 4TI98Z838E, UI: D004958)

Breast Neoplasms (UI: D001943, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: Yes); ultrastructure (UI: Q000648, Major: No); Cytosol (UI: D003600, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Electrophoresis, Polyacrylamide Gel (UI: D004591, Major: No); Estradiol (UI: D004958, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: Yes); pharmacology (UI: Q000494, Major: No); Female (UI: D005260, Major: No); Humans (UI: D006801, Major: No); Hydrogen-Ion Concentration (UI: D006863, Major: No); Neoplasm Proteins (UI: D009363, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); pharmacology (UI: Q000494, Major: No); Receptors, Estrogen (UI: D011960, Major: No) - Qualifiers: drug effects (UI: Q000187, Major: No); metabolism (UI: Q000378, Major: Yes); Steroids (UI: D013256, Major: No) - Qualifiers: pharmacology (UI: Q000494, Major: No)

metabolism (1); ultrastructure (0)|metabolism (0)||metabolism (1); pharmacology (0)||||metabolism (0); pharmacology (0)|drug effects (0); metabolism (1)|pharmacology (0)

0|0|0|0|0|0|0|0|0|0

null

1977-03-21

2019-07-06

pubmed: 1977-1-17; medline: 1977-1-17 0:1; entrez: 1977-1-17 0:0

pubmed: 12893; pii: 0009-8981(77)90217-0; doi: 10.1016/0009-8981(77)90217-0

Breast Neoplasms

[]

13,008

1

Burkitt's lymphoma presenting during lactation.

MEDLINE

Manual

NLM

The diagnostic difficulties and treatment failures of Burkitt's lymphoma manifesting during lactation are presented. All 5 cases presented as breast swelling, mimicking mastitis carcinomatosa; those patients actively lactating had fulminant disease, fatal within a few weeks. There was widespread involvement of internal organs. The importance of early correct diagnosis was emphasized and clinicians are alerted to the possibility of Burkitt's lymphoma occurring during lactation without jaw or abdominal presentation. Whether the fulminant manifestation of Burkitt's lymphoma occurring during lactation was coincidental or not, the possibility exists that a favourable milieu for the tumour growth might have been produced or the body immune mechanism lowered.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

0020-7292

Print

14

3

Print

1,976

null

225-31

J I Durodola (JI)

Journal Article (D016428)

Cytarabine (Registry: 04079A1RDZ, UI: D003561); Cyclophosphamide (Registry: 8N3DW7272P, UI: D003520); Methotrexate (Registry: YL5FZ2Y5U1, UI: D008727)

Adolescent (UI: D000293, Major: No); Adult (UI: D000328, Major: No); Autopsy (UI: D001344, Major: No); Breast Diseases (UI: D001941, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); Breast Neoplasms (UI: D001943, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: Yes); drug therapy (UI: Q000188, Major: No); pathology (UI: Q000473, Major: No); Burkitt Lymphoma (UI: D002051, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: Yes); drug therapy (UI: Q000188, Major: No); pathology (UI: Q000473, Major: No); Child (UI: D002648, Major: No); Cyclophosphamide (UI: D003520, Major: No) - Qualifiers: therapeutic use (UI: Q000627, Major: No); Cytarabine (UI: D003561, Major: No) - Qualifiers: therapeutic use (UI: Q000627, Major: No); Diagnosis, Differential (UI: D003937, Major: No); Female (UI: D005260, Major: No); Humans (UI: D006801, Major: No); Lactation (UI: D007774, Major: Yes); Male (UI: D008297, Major: No); Methotrexate (UI: D008727, Major: No) - Qualifiers: therapeutic use (UI: Q000627, Major: No); Pregnancy (UI: D011247, Major: No)

|||diagnosis (0)|diagnosis (1); drug therapy (0); pathology (0)|diagnosis (1); drug therapy (0); pathology (0)||therapeutic use (0)|therapeutic use (0)||||||therapeutic use (0)|

0|0|0|0|0|0|0|0|0|0|0|0|1|0|0|0

null

1977-03-31

2019-08-19

pubmed: 1976-1-1; medline: 1976-1-1 0:1; entrez: 1976-1-1 0:0

pubmed: 13008; doi: 10.1002/j.1879-3479.1976.tb00600.x

Breast Neoplasms

[]

13,018

1

Carcinoma-in-situ of the cerivix treated with colposcopy guided epithelial conization. Report of a 4-7 year follow-up study.

MEDLINE

Manual

NLM

Twenty-five patients with the diagnosis of carcinoma-in-situ (CIS) of the cervix were treated with colposcopy guided epithelial conization. During the follow-up study of 4-7 years' duration, there was no recurrence of CIS in 20 of the 25 patients. Between 6 and 12 months after conization, 3 patients showed recurrence of CIS. Two of these patients were treated with further epithelial conization with no evidence of further recurrence 4 years after the second treatment. The third patient refused to accept further epithelial conization and modified radical hysterectomy was done without any evidence of residual tumour in the hysterectomy specimen. One patient showed stromal invasion in both colposcopically guided biopsy and bone biopsy. Modified radical hysterectomy specimen showed remnants of stromal invasion. One patient with Class IV smear failed to show any atypical transformation zone and cervicitis was proven on colposcopy guided biopsy following treatment with Flagyl. For two of the 25 patients, cytology was Class II and therefore failed to diagnose the pre-malignant condition; but colposcopy showed a grade 3 atypical transformation zone and the presence of CIS was confirmed histologically. Simultaneous use of cytology, colposcopy and colposcopically guided biopsy confirmed the diagnosis of CIS in all cases. The authors recommend colposcopically guided epithelial conization in younger patients, provided the malignant lesion is strictly intra-epithelial, and limited to the ectocervix. Routine follow-up with the aid of cyto-colposcopy remains the key factor in this schedule of therapy.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

0020-7292

Print

14

3

Print

1,976

null

273-9

J T Burrowes (JT); B S Sengupta (BS); V Persaud (V)

Journal Article (D016428)

null

Adult (UI: D000328, Major: No); Carcinoma in Situ (UI: D002278, Major: No) - Qualifiers: pathology (UI: Q000473, Major: No); surgery (UI: Q000601, Major: Yes); Cautery (UI: D002425, Major: No) - Qualifiers: methods (UI: Q000379, Major: No); Cervix Uteri (UI: D002584, Major: No) - Qualifiers: cytology (UI: Q000166, Major: No); pathology (UI: Q000473, Major: No); Colposcopy (UI: D003127, Major: No); Female (UI: D005260, Major: No); Follow-Up Studies (UI: D005500, Major: No); Humans (UI: D006801, Major: No); Middle Aged (UI: D008875, Major: No); Neoplasm Recurrence, Local (UI: D009364, Major: No); Uterine Cervical Neoplasms (UI: D002583, Major: No) - Qualifiers: pathology (UI: Q000473, Major: No); surgery (UI: Q000601, Major: Yes); Vaginal Smears (UI: D014626, Major: No)

|pathology (0); surgery (1)|methods (0)|cytology (0); pathology (0)|||||||pathology (0); surgery (1)|

0|0|0|0|0|0|0|0|0|0|0|0

null

1977-03-31

2019-08-19

pubmed: 1976-1-1; medline: 1976-1-1 0:1; entrez: 1976-1-1 0:0

pubmed: 13018; doi: 10.1002/j.1879-3479.1976.tb00610.x

Breast Neoplasms

['Neoplasm Recurrence, Local']

13,805

1

Acute-phase reactant protein profiles: an aid to monitoring large bowel cancer by CEA and serum enzymes.

MEDLINE

Manual

NLM

The profiles of 4 acute-phase reactant proteins (APRPs) (haptoglobin (HPT), alpha1 antitrypsin (AAT), alpha1 acid glycoprotein (AGP) and prealbumin (PALB)) have been studied during the evolution of bowel cancer. Serial measurements of these APRPs can add to the information obtained from measurements of the level of CEA and hepatic enzymes during the monitoring of postoperative patients. There is considerable stability in the profile in a given individual in health, Rises of AAT and AGP are associated with metastases. High levels of HPT may suggest involvement of the bowel wall by recurrent cancer. PALB levels tend to reflect the nutritional status. A discriminant function based on the log CEA, AAT and AGP preoperative blood levels can considerably improve on the predictive value attained using CEA levels alone.

British journal of cancer

0007-0920

Print

35

2

Print

1,977

Feb

null

170-8

A M Ward (AM); E H Cooper (EH); R Turner (R); J A Anderson (JA); A M Neville (AM)

Journal Article (D016428)

Carcinoembryonic Antigen (Registry: 0, UI: D002272); Haptoglobins (Registry: 0, UI: D006242); Orosomucoid (Registry: 0, UI: D009961); Prealbumin (Registry: 0, UI: D011228); Serum Albumin (Registry: 0, UI: D012709); alpha 1-Antitrypsin (Registry: 0, UI: D000515); gamma-Glutamyltransferase (Registry: EC 2.3.2.2, UI: D005723)

Aged (UI: D000368, Major: No); Carcinoembryonic Antigen (UI: D002272, Major: No) - Qualifiers: analysis (UI: Q000032, Major: Yes); Colonic Neoplasms (UI: D003110, Major: No) - Qualifiers: blood (UI: Q000097, Major: Yes); immunology (UI: Q000276, Major: No); surgery (UI: Q000601, Major: No); Female (UI: D005260, Major: No); Haptoglobins (UI: D006242, Major: No) - Qualifiers: analysis (UI: Q000032, Major: Yes); Humans (UI: D006801, Major: No); Middle Aged (UI: D008875, Major: No); Neoplasm Metastasis (UI: D009362, Major: No); Neoplasm Recurrence, Local (UI: D009364, Major: No); Orosomucoid (UI: D009961, Major: No) - Qualifiers: analysis (UI: Q000032, Major: Yes); Prealbumin (UI: D011228, Major: No) - Qualifiers: analysis (UI: Q000032, Major: Yes); Serum Albumin (UI: D012709, Major: No) - Qualifiers: analysis (UI: Q000032, Major: Yes); alpha 1-Antitrypsin (UI: D000515, Major: No) - Qualifiers: analysis (UI: Q000032, Major: Yes); gamma-Glutamyltransferase (UI: D005723, Major: No) - Qualifiers: blood (UI: Q000097, Major: No)

|analysis (1)|blood (1); immunology (0); surgery (0)||analysis (1)|||||analysis (1)|analysis (1)|analysis (1)|analysis (1)|blood (0)

0|0|0|0|0|0|0|0|0|0|0|0|0|0

null

1977-04-28

2019-05-15

pubmed: 1977-2-1; medline: 1977-2-1 0:1; entrez: 1977-2-1 0:0

pubmed: 4444457; pmc: PMC2025326; doi: 10.1038/bjc.1977.24

Breast Neoplasms

['Neoplasm Metastasis', 'Neoplasm Recurrence, Local']

14,041

1

Comparison of the in vitro conversion of estradiol-17 beta to estrone of normal and neoplastic human breast tissue.

MEDLINE

Manual

NLM

Specific activity of 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) was measured in 48 tissue specimens of human female breast cancer and, in addition, 48 nonmalignant tissue specimens obtained in each case from the same cancer-bearing breast. In all cases the nonmalignant tissue showed greater conversion of estradiol-17 beta into estrone than the neoplastic tissues. In normal human breast tissue of premenopausal women specific enzyme activity depended on the phase of the MENSTRUAL CYCLE: the highest values of 17 beta-HSD activity were found in the early secretory phase. To determine the intracellular distribution of the 17 beta-HSD, purified microsomes, mitochondria, peroxysomes, lysosomes, nuclei and cytosol fractions were prepared. The purity of each fraction was monitored by marker enzymes. It was found that the 17 beta-HSD was mainly located in mitochondria and microsomes. Furthermore it could be demonstrated that the microsomal enzyme was bound tightly to the membranes of the endoplasmic reticulum, while the mitochondrial 17 beta-HSD was mainly associated with the outer membranes of the organelle. Kinetic parameters (Km-values, coenzyme requirements and maximal velocities) of a cytoplasmic, nuclear, mitochondrial and microsomal 17 beta-HSD of normal and neoplastic human mammary tissue were compared. Maximal velocity was highest in enzyme preparations of normal mammary tissue obtained from premenopausal women in the early secretory phase. Km-values wrere nearly identical in normal and neoplastic mammary tissue preparations (approx. 1 X 10(-6) M). NAD was more efficient than NADP as a cofactor. For the conversion of estradiol to estrone the optimum temperature was approximately 40 degrees C and the optimum pH 9.5. For the reduction of estrone the optimum pH was 6.5. Sulphydryl groups were shown to be essential for catalysis.

Molecular and cellular endocrinology

0303-7207

Print

6

4-5

Print

1,977

Feb

null

333-48

K Pollow (K); E Boquoi (E); J Baumann (J); M Schmidt-Gollwitzer (M); B Pollow (B)

Comparative Study (D003160); Journal Article (D016428)

Sulfhydryl Reagents (Registry: 0, UI: D013439); Estrone (Registry: 2DI9HA706A, UI: D004970); Estradiol (Registry: 4TI98Z838E, UI: D004958); Hydroxysteroid Dehydrogenases (Registry: EC 1.1.-, UI: D006913); Estradiol Dehydrogenases (Registry: EC 1.1.1.62, UI: D004960)

Breast (UI: D001940, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: Yes); ultrastructure (UI: Q000648, Major: No); Breast Neoplasms (UI: D001943, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: Yes); Endoplasmic Reticulum (UI: D004721, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: No); Estradiol (UI: D004958, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Estradiol Dehydrogenases (UI: D004960, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: Yes); Estrone (UI: D004970, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Female (UI: D005260, Major: No); Humans (UI: D006801, Major: No); Hydrogen-Ion Concentration (UI: D006863, Major: No); Hydroxysteroid Dehydrogenases (UI: D006913, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: Yes); In Vitro Techniques (UI: D066298, Major: No); Kinetics (UI: D007700, Major: No); Menopause (UI: D008593, Major: No); Menstruation (UI: D008598, Major: No); Microsomes (UI: D008861, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: No); Mitochondria (UI: D008928, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: No); Sulfhydryl Reagents (UI: D013439, Major: No) - Qualifiers: pharmacology (UI: Q000494, Major: No); Temperature (UI: D013696, Major: No)

enzymology (1); ultrastructure (0)|enzymology (1)|enzymology (0)|metabolism (0)|metabolism (1)|metabolism (0)||||metabolism (1)|||||enzymology (0)|enzymology (0)|pharmacology (0)|

0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0

null

1977-04-30

2019-08-13

pubmed: 1977-2-1; medline: 1977-2-1 0:1; entrez: 1977-2-1 0:0

pubmed: 14041; doi: 10.1016/0303-7207(77)90108-3

Breast Neoplasms

[]

15,396

1

Myxofibrosarcoma. A study of 30 cases.

MEDLINE

Manual

NLM

A series of 30 myxofibrosarcomas is described. These malignant soft tissue tumours are characterized by a mucoid and nodular appearance, a coarse plexiform capillary pattern, and they are mostly seen subcutaneously (26 out of 30) in the extremities (24 out of 30) and trunk (4 out of 30) elderly people. Histochemical studies, comprising staining with Alcian blue and toluidine blue at different pH's with and without preceding digestion with testicular hyaluronidase and with the Scott technique, indicated the presence of hyaluronic acid but not sulphated glycosaminoglycans as chondroitinsulphates. Myxofibrosarcoma is believed to belong to the general category of fibroblastic and histiocytic malignant soft tissue tumours. The median diameter of the tumours was 7 cm. They were divided into 4 grades according to cellularity, cell atypia and mitotic activity. The grade III and IV tumours showed pronounced atypia, often with the bi- and multinucleated giant tumour cells and occasionally with giant cells of Touton's type, suggesting a relationship to malignant fibroxanthoma. All of the patients were treated surgically and one received also pre- and post-operative irradiation. None of the 2 grade I myxofibrosarcomas recurred, while 2 out of 7 grade II tumours, 6 out of 10 grade III tumours, and 7 out of 11 grade IV tumours recurred once and up to 9 times. Metastasis appeared in 7 out of 30 patients; grade I tumours were not seen in any of these cases. By the time of follow-up after intervals ranging from 1 month up to 27 years, 14 patients had died; 6 of these had died post-operatively or of intercurrent disease. The differential diagnosis between myxofibrosarcoma and other myxoid soft tissue tumours is discussed.

Acta pathologica et microbiologica Scandinavica. Section A, Pathology

0365-4184

Print

85A

2

Print

1,977

Mar

null

127-40

L Angervall (L); L G Kindblom (LG); C Merck (C)

Journal Article (D016428)

Tolonium Chloride (Registry: 15XUH0X66N, UI: D014048); Alcian Blue (Registry: P4448TJR7J, UI: D000423)

Adult (UI: D000328, Major: No); Age Factors (UI: D000367, Major: No); Aged (UI: D000368, Major: No); Alcian Blue (UI: D000423, Major: No); Female (UI: D005260, Major: No); Fibrosarcoma (UI: D005354, Major: Yes) - Qualifiers: diagnosis (UI: Q000175, Major: No); pathology (UI: Q000473, Major: No); surgery (UI: Q000601, Major: No); Follow-Up Studies (UI: D005500, Major: No); Humans (UI: D006801, Major: No); Hydrogen-Ion Concentration (UI: D006863, Major: No); Male (UI: D008297, Major: No); Middle Aged (UI: D008875, Major: No); Neoplasm Metastasis (UI: D009362, Major: No); Neoplasm Recurrence, Local (UI: D009364, Major: No); Prognosis (UI: D011379, Major: No); Sex Factors (UI: D012737, Major: No); Soft Tissue Neoplasms (UI: D012983, Major: Yes) - Qualifiers: diagnosis (UI: Q000175, Major: No); pathology (UI: Q000473, Major: No); surgery (UI: Q000601, Major: No); Tolonium Chloride (UI: D014048, Major: No)

|||||diagnosis (0); pathology (0); surgery (0)||||||||||diagnosis (0); pathology (0); surgery (0)|

0|0|0|0|0|1|0|0|0|0|0|0|0|0|0|1|0

null

1977-05-12

2022-03-09

pubmed: 1977-3-1; medline: 1977-3-1 0:1; entrez: 1977-3-1 0:0

pubmed: 15396

Breast Neoplasms

['Neoplasm Metastasis', 'Neoplasm Recurrence, Local']

15,722

1

Adrenergic, cholinergic, and inactive human neuroblastoma cell lines with the action-potential Na+ ionophore.

MEDLINE

Manual

NLM

Cultured human neuroblastoma cell lines were assayed for biochemical characteristics of neuonal function. Cell lines studied included LA-N-1, LA-N-2, IMR-32, SK-N-SH, and SK-N-MC. Veratridine-dependent uptake of 22Na+ implied the presence of the action potential Na+ ionophore in LA-N-1, LA-N-2, IMR-32, and SK-N-SH. The time course of 22Na+ uptake and inhibition of uptake by tetrodotoxin supported this. SK-N-MC had no veratridine-dependent 22Na+ uptake. Tyrosine hydroxylase (EC 1.14.10.), glutamic acid decarboxylase (EC 4.1.1.15), and acetylcholine contents in neuroblastoma cells were compared to those in brain. LA-N-1 and IMR-32 contained 15 and 5 times as much tyrosine hydroxylase, respectively, whereas LA-N-2, SK-N-SH, and SK-N-MC contained only 0.5 to 5% of that in brain. Acetylcholine was present in -LA-N-2 in 15- to 20-fold greater quantities than in brain; other lines had only 10 to 50% of that in brain. None of the cell lines contained glutamic acid decarboxylase. Thus, continuously propogated human neuroblastoma cell lines may have the action potential Na+ ionophore and may be adrenergic (LA-N-1 and IMR-32), cholinergic (LA-N-2), or inactive (SK-N-SH and SK-N-MC). This is the first demonstration of the action potential Na+ ionophore and of acetylcholine production in human neuroblastoma cell lines.

Cancer research

0008-5472

Print

37

5

Print

1,977

May

null

1372-6

G J West (GJ); J Uki (J); H R Herschman (HR); R C Seeger (RC)

Journal Article (D016428); Research Support, U.S. Gov't, Non-P.H.S. (D013486)

Ionophores (Registry: 0, UI: D007476); Sympathomimetics (Registry: 0, UI: D013566); Sodium (Registry: 9NEZ333N27, UI: D012964); Tyrosine 3-Monooxygenase (Registry: EC 1.14.16.2, UI: D014446); Glutamate Decarboxylase (Registry: EC 4.1.1.15, UI: D005968); Veratrine (Registry: ERQ7M6C50B, UI: D014702); Acetylcholine (Registry: N9YNS0M02X, UI: D000109)

Acetylcholine (UI: D000109, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: Yes); Action Potentials (UI: D000200, Major: No); Cell Line (UI: D002460, Major: Yes); Glutamate Decarboxylase (UI: D005968, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Humans (UI: D006801, Major: No); Ionophores (UI: D007476, Major: No); Neoplasm Metastasis (UI: D009362, Major: No); Neuroblastoma (UI: D009447, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: Yes); Sodium (UI: D012964, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: Yes); Sympathomimetics (UI: D013566, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: Yes); Tyrosine 3-Monooxygenase (UI: D014446, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Veratrine (UI: D014702, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No)

metabolism (1)|||metabolism (0)||||metabolism (1)|metabolism (1)|metabolism (1)|metabolism (0)|metabolism (0)

0|0|1|0|0|0|0|0|0|0|0|0

null

1977-06-22

2013-11-21

pubmed: 1977-5-1; medline: 1977-5-1 0:1; entrez: 1977-5-1 0:0

pubmed: 15722

Breast Neoplasms

['Neoplasm Metastasis']

16,202

1

A study of cancer of the breast with special reference to its causation and prevention.

MEDLINE

Manual

NLM

Breast feeding, lactational histories, parity, age at marriage, and socio-economic status were compared in 24 patients with carcinoma of breast, 24 healthy controls, and 48 patients suffering from other diseases. They were matched for age, social class and work or trade of the husbands. Breast cancer patients married later, had shorter lactational histories and had fewer children as compared with controls. Studies in six healthy mothers showed that milk became more alkaline on stasis in the breast. This study confirms the view that breast feeding protects against breast cancer. It suggests that one carcinogenic factor may be an alkaline milieu produced by the statis of milk in the breasts. An alkaline milieu surrounding epithelial surfaces produces cell proliferation and a marked increase in mitotic activity which may eventually lead to metaplasia and neoplasia.

Medical hypotheses

0306-9877

Print

3

1

Print

null

21-4

S L Malhotra (SL)

Journal Article (D016428)

null

Age Factors (UI: D000367, Major: No); Breast Feeding (UI: D001942, Major: No); Breast Neoplasms (UI: D001943, Major: No) - Qualifiers: etiology (UI: Q000209, Major: Yes); Female (UI: D005260, Major: No); Humans (UI: D006801, Major: No); Hydrogen-Ion Concentration (UI: D006863, Major: No); Lactation (UI: D007774, Major: No); Milk, Human (UI: D008895, Major: No); Parity (UI: D010298, Major: No); Pregnancy (UI: D011247, Major: No); Socioeconomic Factors (UI: D012959, Major: No)

||etiology (1)||||||||

0|0|0|0|0|0|0|0|0|0|0

null

1977-06-11

2019-08-19

pubmed: 1977-1-1; medline: 1977-1-1 0:1; entrez: 1977-1-1 0:0

pubmed: 16202; pii: 0306-9877(77)90047-0; doi: 10.1016/0306-9877(77)90047-0

Breast Neoplasms

[]

17,095

1

[Diagnosis of hepatic metastasis by enzymatic assay. Value of gamma-glutamyltranspeptidase].

MEDLINE

Manual

NLM

Variations in serum enzyme levels were studied in 50 patients suffering from various types of neoplasm, 25 of whom had hepatic metastases. In the absence of any associated hepato-biliary or pancreatic disorder, gamma-glutamyl-transpeptidase would appear to be a reliable test in 96 % of cases. It represents a factor of assessment which merits a place in the prognostic study of all types of neoplasia.

La Nouvelle presse medicale

0301-1518

Print

6

19

Print

1,977

May

7

1635-7

G Champault (G); M Garnier (M); J C Patel (JC)

English Abstract (D004740); Journal Article (D016428)

gamma-Glutamyltransferase (Registry: EC 2.3.2.2, UI: D005723); Transaminases (Registry: EC 2.6.1.-, UI: D000637); Alkaline Phosphatase (Registry: EC 3.1.3.1, UI: D000469); N-Glycosyl Hydrolases (Registry: EC 3.2.2.-, UI: D009699)

Adult (UI: D000328, Major: No); Aged (UI: D000368, Major: No); Alkaline Phosphatase (UI: D000469, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Clinical Enzyme Tests (UI: D004796, Major: No); Female (UI: D005260, Major: No); Humans (UI: D006801, Major: No); Liver Neoplasms (UI: D008113, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: Yes); enzymology (UI: Q000201, Major: No); Male (UI: D008297, Major: No); Middle Aged (UI: D008875, Major: No); N-Glycosyl Hydrolases (UI: D009699, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Neoplasm Metastasis (UI: D009362, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: Yes); enzymology (UI: Q000201, Major: No); Transaminases (UI: D000637, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); gamma-Glutamyltransferase (UI: D005723, Major: No) - Qualifiers: blood (UI: Q000097, Major: Yes)

||blood (0)||||diagnosis (1); enzymology (0)|||blood (0)|diagnosis (1); enzymology (0)|blood (0)|blood (1)

0|0|0|0|0|0|0|0|0|0|0|0|0

null

1977-07-29

2007-11-15

pubmed: 1977-5-7; medline: 1977-5-7 0:1; entrez: 1977-5-7 0:0

pubmed: 17095

Breast Neoplasms

['Neoplasm Metastasis']

20,356

1

Acute carcinomatous myopathy associated with ovarian carcinoma.

MEDLINE

Manual

NLM

A case of acute, fatal, rapidly progressive pure myopathy associated with ovarian carcinoma is described. The first symptoms of carcinomatous myopathy occurred 8 months after surgical treatment and combined chemotherapy. The patient died 2 months after onset of myopathy. The clinical and pathologic findings of the myopathy are discussed.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

0020-7292

Print

14

6

Print

1,976

null

533-6

E Magyar (E); A Talerman (A)

Case Reports (D002363); Journal Article (D016428)

null

Adult (UI: D000328, Major: No); Cystadenoma (UI: D003537, Major: No) - Qualifiers: complications (UI: Q000150, Major: Yes); pathology (UI: Q000473, Major: No); Female (UI: D005260, Major: No); Humans (UI: D006801, Major: No); Muscular Diseases (UI: D009135, Major: No) - Qualifiers: etiology (UI: Q000209, Major: Yes); pathology (UI: Q000473, Major: No); Neoplasm Metastasis (UI: D009362, Major: No); Ovarian Neoplasms (UI: D010051, Major: No) - Qualifiers: complications (UI: Q000150, Major: Yes); pathology (UI: Q000473, Major: No)

|complications (1); pathology (0)|||etiology (1); pathology (0)||complications (1); pathology (0)

0|0|0|0|0|0|0

null

1977-11-25

2019-08-19

pubmed: 1976-1-1; medline: 1976-1-1 0:1; entrez: 1976-1-1 0:0

pubmed: 20356; doi: 10.1002/j.1879-3479.1976.tb00102.x

Breast Neoplasms

['Neoplasm Metastasis']

21,041

1

Value of alkaline phosphatase, 5'-nucleotidase, gamma-glutamyltransferase, and glutamate dehydrogenase activity measurements (single and combined) in serum in diagnosis of metastasis to the liver.

MEDLINE

Manual

NLM

We assessed, in 98 patients with cancer, the diagnostic value of measuring serum alkaline phosphatase, 5'-nucleotidase, gamma-glutamyltransferase, and glutamate dehydrogenase activities as an aid to detection of liver metastases. All four enzymes showed diagnostic value, but 5'-nucleotidase appeared to have the greatest. It showed the lowest false-positive results (7.4%) with the highest predictive value of a positive test (85.7%) and agreement (81.3%).. gamma-Glutamyltransferase showed the lowest proportion of false-negative results (2.8%), but was the least specific 35% false-positive results). Analysis of various test combinations showed that the best agreement (77.5%) was obtained when the patients were divided into those who had no or only one abnormal test result, and those who had two or more abnormal test results. However, this was not better than the agreement for 5' nucleotidase alone (81.3%). The agreement of 5'-nucleotidase and gamma-glutamyltransferase (i.e., both tests were positive or negative) was excellent (91.4%), but such agreement included only 67% of the patients with liver metastases.

Clinical chemistry

0009-9147

Print

23

11

Print

1,977

Nov

null

2034-8

N K Kim (NK); W G Yasmineh (WG); E F Freier (EF); A I Goldman (AI); A Theologides (A)

Journal Article (D016428); Research Support, U.S. Gov't, P.H.S. (D013487)

Glutamate Dehydrogenase (Registry: EC 1.4.1.2, UI: D005969); gamma-Glutamyltransferase (Registry: EC 2.3.2.2, UI: D005723); Nucleotidases (Registry: EC 3.1.3.-, UI: D009708); Alkaline Phosphatase (Registry: EC 3.1.3.1, UI: D000469)

Alkaline Phosphatase (UI: D000469, Major: No) - Qualifiers: blood (UI: Q000097, Major: Yes); Clinical Enzyme Tests (UI: D004796, Major: No); Female (UI: D005260, Major: No); Glutamate Dehydrogenase (UI: D005969, Major: No) - Qualifiers: blood (UI: Q000097, Major: Yes); Humans (UI: D006801, Major: No); Liver Neoplasms (UI: D008113, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); Male (UI: D008297, Major: No); Neoplasm Metastasis (UI: D009362, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: Yes); Nucleotidases (UI: D009708, Major: No) - Qualifiers: blood (UI: Q000097, Major: Yes); gamma-Glutamyltransferase (UI: D005723, Major: No) - Qualifiers: blood (UI: Q000097, Major: Yes)

blood (1)|||blood (1)||diagnosis (0)||diagnosis (1)|blood (1)|blood (1)

0|0|0|0|0|0|0|0|0|0

null

1977-12-29

2019-07-22

pubmed: 1977-11-1; medline: 1977-11-1 0:1; entrez: 1977-11-1 0:0

pubmed: 21041

Breast Neoplasms

['Neoplasm Metastasis']

22,288

1

[The influence of preoperative irradiation on postoperative complications in surgical treatment of carcinoma of the esophagus].

MEDLINE

Manual

NLM

Over a 15 year period, the authors operated upon 650 patients suffering from carcinoma of the oesophagus. Amongst them, 185 underwent pre-operative irradiation. The latter appears to increase the percentage in whom excision was possible. By contrast, the occurence rate of postoperative complications is essentially the same in both groups of patients apart from chylothorax which was more common in the irradiated subjects.

Annales de l'anesthesiologie francaise

0003-4061

Print

18

4

Print

1,977

null

393-6

E Negre (E); H Pujol (H); P A Chaptal (PA); J C Bordart (JC)

Comparative Study (D003160); English Abstract (D004740); Journal Article (D016428)

null

Chylothorax (UI: D002916, Major: No) - Qualifiers: etiology (UI: Q000209, Major: No); Esophageal Neoplasms (UI: D004938, Major: No) - Qualifiers: radiotherapy (UI: Q000532, Major: Yes); surgery (UI: Q000601, Major: Yes); Humans (UI: D006801, Major: No); Neoplasm Recurrence, Local (UI: D009364, Major: No); Postoperative Complications (UI: D011183, Major: Yes); Preoperative Care (UI: D011300, Major: No)

etiology (0)|radiotherapy (1); surgery (1)||||

0|0|0|0|1|0

null

1978-01-27

2006-11-15

pubmed: 1977-1-1; medline: 1977-1-1 0:1; entrez: 1977-1-1 0:0

pubmed: 22288

Breast Neoplasms

['Neoplasm Recurrence, Local']

22,554

1

Studies on human alpha-lactalbumin: radioimmunoassay measurements in normal human breast and breast cancer.

MEDLINE

Manual

NLM

A sensitive and specific radioimmunoassay for human alpha-lactalbumin, a milk protein, has been developed in order to examine the effect of prolactin on the human breast in normal and diseased states. Samples of milk from nursing mothers and from men and women with galactorrhea were found to contain milligram concentrations of this protein. In serum, 8 of 25 normal men and 18 of 44 normal women had detectable concentrations of alpha-lactalbumin. Significantly higher levels of alpha-lactalbumin were found in 17 of 19 women during pregnancy who were not actively lactating. All nursing mothers were found to have distinctly elevated serum alpha-lactalbumin concentrations. In a group of 17 female patients with phenothiazine induced prolactin elevations (mean 29.4 ng/ml), the mean serum alpha-lactalbumin of 17.3 ng/ml was significantly higher than in normal female volunteers. Patients with gynecomastia were not noted to have elevated alpha-lactalbumin. In vitro, homogenates of normal breast and carcinoma tissue from the same individuals revealed that in 9 of 17 patients alpha-lactalbumin was present in higher concentrations in normal than in cancerous tissue. Overall, alpha-lactalbumin was found in 48.5% of homogenates and 41% of organ cultures of normal breast tissue from cancer patients. In contrast, it was present in only 19% of homogenates and 21% of cultures of carcinoma tissue, indicating that the cancer tissue may lose its ability to produce alpha-lactalbumin. Differences in biologic behavior were found in some tumors. In 2 cases homogenates of breast cancer tissue had much higher concentrations of alpha-lactalbumin than the normal tissue, and in 3 of 33 tumors studied in organ culture prolactin increased alpha-lactalbumin output.

The Journal of clinical endocrinology and metabolism

0021-972X

Print

45

6

Print

1,977

Dec

null

1238-50

D L Kleinberg (DL); J Todd (J); M L Groves (ML)

Journal Article (D016428); Research Support, U.S. Gov't, Non-P.H.S. (D013486); Research Support, U.S. Gov't, P.H.S. (D013487)

Antipsychotic Agents (Registry: 0, UI: D014150); Phenothiazines (Registry: 0, UI: D010640); Lactalbumin (Registry: 9013-90-5, UI: D007768)

Adolescent (UI: D000293, Major: No); Adult (UI: D000328, Major: No); Aged (UI: D000368, Major: No); Animals (UI: D000818, Major: No); Antipsychotic Agents (UI: D014150, Major: No) - Qualifiers: therapeutic use (UI: Q000627, Major: No); Breast (UI: D001940, Major: No) - Qualifiers: analysis (UI: Q000032, Major: Yes); Breast Neoplasms (UI: D001943, Major: No) - Qualifiers: analysis (UI: Q000032, Major: Yes); Cell Line (UI: D002460, Major: No); Child (UI: D002648, Major: No); Child, Preschool (UI: D002675, Major: No); Female (UI: D005260, Major: No); Gynecomastia (UI: D006177, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Haplorhini (UI: D000882, Major: No); Humans (UI: D006801, Major: No); Lactalbumin (UI: D007768, Major: No) - Qualifiers: analysis (UI: Q000032, Major: Yes); blood (UI: Q000097, Major: No); Male (UI: D008297, Major: No); Middle Aged (UI: D008875, Major: No); Milk, Human (UI: D008895, Major: No) - Qualifiers: analysis (UI: Q000032, Major: No); Organ Culture Techniques (UI: D009924, Major: No); Papio (UI: D010215, Major: No); Phenothiazines (UI: D010640, Major: No); Pregnancy (UI: D011247, Major: No); Radioimmunoassay (UI: D011863, Major: No)

||||therapeutic use (0)|analysis (1)|analysis (1)|||||blood (0)|||analysis (1); blood (0)|||analysis (0)|||||

0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0

null

1978-02-18

2006-11-15

pubmed: 1977-12-1; medline: 1977-12-1 0:1; entrez: 1977-12-1 0:0

pubmed: 22554; doi: 10.1210/jcem-45-6-1238

Breast Neoplasms

[]

23,645

1

[Painful ophthalmoplegia (author's transl)].

MEDLINE

Manual

NLM

The authors begin by enumerating the various syndromes in which painful ophthalmoplegia may be observed (sphenoidal fissure syndrome, Collier's syndrome, syndromes involving the orbital apex, the cavernous sinus and parasellar syndromes; Raeder's syndrome, Gradenigo's syndrome and Fischer-Brugge syndrome). They then discuss the various causes that must be investigated in all cases of painful ophtalmoplegia. They consider in order: -- ophtalmoplegia due to general causes (especially diabetes) and neurological causes (e.g. multiple sclerosis); -- ophtalmoplegia due to common local canses space-occupying processes, vascular malformations, ear, nose and larynx infections); -- painful ophalmoplegia of unknown origin, which includes four entities of very differing importance (Gubler and Charcot's ophthalmoplegic migraine and Tolosa-Hunt syndrome of which the clinical symptoms and course are so different that they can be distinguished as two entities; and, secondarily, inflammatory pseudo-tumours of the orbit and the recurrent multiple cranial nerve palsies that are observed in South-East Asia). (Acta nurol. belg., 1977, 77, 331-350).

Acta neurologica Belgica

0300-9009

Print

77

6

Print

1,977

null

331-50

J Lapresle (J); M Desi (M)

English Abstract (D004740); Journal Article (D016428)

null

Diabetes Complications (UI: D048909, Major: No); Diagnosis, Differential (UI: D003937, Major: No); Functional Laterality (UI: D007839, Major: No); Humans (UI: D006801, Major: No); Migraine Disorders (UI: D008881, Major: No) - Qualifiers: complications (UI: Q000150, Major: No); Neoplasm Metastasis (UI: D009362, Major: No); Ophthalmoplegia (UI: D009886, Major: No) - Qualifiers: complications (UI: Q000150, Major: Yes); diagnosis (UI: Q000175, Major: No); Orbital Neoplasms (UI: D009918, Major: No) - Qualifiers: complications (UI: Q000150, Major: No); Pain (UI: D010146, Major: No) - Qualifiers: etiology (UI: Q000209, Major: Yes); Polyarteritis Nodosa (UI: D010488, Major: No) - Qualifiers: complications (UI: Q000150, Major: No); Recurrence (UI: D012008, Major: No); Sarcoidosis (UI: D012507, Major: No) - Qualifiers: complications (UI: Q000150, Major: No); Syphilis (UI: D013587, Major: No) - Qualifiers: complications (UI: Q000150, Major: No)

||||complications (0)||complications (1); diagnosis (0)|complications (0)|etiology (1)|complications (0)||complications (0)|complications (0)

0|0|0|0|0|0|0|0|0|0|0|0|0

null

1978-03-29

2006-11-15

pubmed: 1977-1-1; medline: 1977-1-1 0:1; entrez: 1977-1-1 0:0

pubmed: 23645

Breast Neoplasms

['Neoplasm Metastasis']

24,912

1

Pathology of germ cell tumors of the testis.

MEDLINE

Manual

NLM

Testicular germ cell tumors form a complex group of interrelated entities. Problems of nomenclature remain, but there does appear to be a close agreement between the major classifications in use. The identification of clinically useful markers for certain germ cell testicular tumors has provided a major impetus in this field. Information gained from the study of these markers has promoted an understanding of the histogenesis of germ cell tumors, has improved standard nomenclature, and has stimulated progress in patient care. Radioimmunoassay techniques are now frequently used to measure beta-human chorionic gonadotrophin and alpha-fetoprotein levels in evaluating the clinical course of patients with nonseminomatous germ cell tumors of the testis. It is hoped that the use of these markers will permit earlier detection of tumor recurrence, prompt treatment, and an improved survival rate. The knowledge of the production of alpha-fetoprotein by the human yolk sac has further refined tumor classification. It is against this general background that we have outlined the standard pathology of germ cell tumors of the testis.

The Urologic clinics of North America

0094-0143

Print

4

3

Print

1,977

Oct

null

359-78

L E Nochomovitz (LE); F E DeLa Torre (FE); J Rosai (J)

Journal Article (D016428); Review (D016454)

null

Choriocarcinoma (UI: D002822, Major: No) - Qualifiers: pathology (UI: Q000473, Major: No); Cryptorchidism (UI: D003456, Major: No) - Qualifiers: complications (UI: Q000150, Major: No); Dysgerminoma (UI: D004407, Major: No) - Qualifiers: etiology (UI: Q000209, Major: No); pathology (UI: Q000473, Major: No); Humans (UI: D006801, Major: No); Male (UI: D008297, Major: No); Neoplasm Metastasis (UI: D009362, Major: No); Teratoma (UI: D013724, Major: No) - Qualifiers: pathology (UI: Q000473, Major: No); Testicular Neoplasms (UI: D013736, Major: No) - Qualifiers: classification (UI: Q000145, Major: No); etiology (UI: Q000209, Major: No); pathology (UI: Q000473, Major: Yes)

pathology (0)|complications (0)|etiology (0); pathology (0)||||pathology (0)|classification (0); etiology (0); pathology (1)

0|0|0|0|0|0|0|0

null

1978-05-08

2004-11-17

pubmed: 1977-10-1; medline: 1977-10-1 0:1; entrez: 1977-10-1 0:0

pubmed: 24912

Breast Neoplasms

['Neoplasm Metastasis']

25,754

1

[Surgery of pancreatic endocrine tumours in the German Federal Republic: results of a survey (author's transl)].

MEDLINE

Manual

NLM

Within a ten-year scan (1967-1976) 207 insulinomas, 50 gastrinomas, 8 Verner-Morrison tumors, 5 glucagonomas and 12 endocrine pancreatic tumours with associated MEA syndrome (multiple endocrine adenomatosis) were treated surgically at various university hospitals (information obtained by questionnaire). Half of the insulinomas were treated by enucleation, one third by resection of the tail of the pancreas. Total gastrectomy was the procedure of choice in 80% of patients with gastrinoma, but sometimes pancreatic resection to remove the tumour was added. An new therapeutic concept of using histamine-H2 receptor antagonists for treating patients with Zollinger-Ellison syndrome is discussed. In the eight patients with a Verner-Morrison syndrome removal of the tumour or distal pancreatic resection was the procedure of choice.

Deutsche medizinische Wochenschrift (1946)

0012-0472

Print

103

17

Print

1,978

Apr

28

729-32

F Kümmerle (F); K Rückert (K)

Journal Article (D016428)

Gastrins (Registry: 0, UI: D005755); Histamine H2 Antagonists (Registry: 0, UI: D006635); Glucagon (Registry: 9007-92-5, UI: D005934)

Acute Kidney Injury (UI: D058186, Major: No) - Qualifiers: surgery (UI: Q000601, Major: No); Adenoma, Islet Cell (UI: D007516, Major: No) - Qualifiers: surgery (UI: Q000601, Major: No); Dehydration (UI: D003681, Major: No) - Qualifiers: surgery (UI: Q000601, Major: No); Gastrectomy (UI: D005743, Major: No); Gastrins (UI: D005755, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Glucagon (UI: D005934, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Histamine H2 Antagonists (UI: D006635, Major: No) - Qualifiers: therapeutic use (UI: Q000627, Major: No); Humans (UI: D006801, Major: No); Neoplasm Metastasis (UI: D009362, Major: No); Pancreatectomy (UI: D010180, Major: No); Pancreatic Neoplasms (UI: D010190, Major: No) - Qualifiers: surgery (UI: Q000601, Major: Yes); Statistics as Topic (UI: D013223, Major: No); Syndrome (UI: D013577, Major: No); Zollinger-Ellison Syndrome (UI: D015043, Major: No) - Qualifiers: drug therapy (UI: Q000188, Major: No)

surgery (0)|surgery (0)|surgery (0)||metabolism (0)|metabolism (0)|therapeutic use (0)||||surgery (1)|||drug therapy (0)

0|0|0|0|0|0|0|0|0|0|0|0|0|0

null

1978-07-15

2018-11-30

pubmed: 1978-4-28; medline: 1978-4-28 0:1; entrez: 1978-4-28 0:0

pubmed: 25754; doi: 10.1055/s-0028-1104791

Breast Neoplasms

['Neoplasm Metastasis']

26,256

1

[Laparoscopic findings in aged patients (author's transl)].

MEDLINE

Manual

NLM

A group of 165 geriatric patients is compared with a control group of 114 younger patients concerning different frequency of laparoscopic diagnoses. As it was suspected from the clinical view aged patients predominently suffered from posthepatic cirrhosis and from cirrhosis of unknown origin, from recurrent cholecystitis, obstructive jaundice, metastases and carcinosis of peritoneal cavity. Younger patients much more frequently showed toxic liver damage starting from fatty liver and ending up with fatty liver cirrhosis. Persistent acute hepatitis non associated with HBSAg was scarcely seen with the aged group. It was a frequent diagnosis with the younger control group. There are explanations given for the differing endoscopic results concerning aged persons and younger control persons.

Aktuelle Gerontologie

0300-5704

Print

8

3

Print

1,978

Mar

null

143-8

H O Müller (HO); V Salamon (V); B May (B); W Pohle (W)

Comparative Study (D003160); English Abstract (D004740); Journal Article (D016428)

null

Adult (UI: D000328, Major: No); Aged (UI: D000368, Major: No); Cholecystitis (UI: D002764, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); Cholestasis (UI: D002779, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); Geriatrics (UI: D005853, Major: Yes); Germany, West (UI: D005860, Major: No); Hepatitis (UI: D006505, Major: No) - Qualifiers: complications (UI: Q000150, Major: No); Humans (UI: D006801, Major: No); Laparoscopy (UI: D010535, Major: Yes) - Qualifiers: methods (UI: Q000379, Major: No); Liver Cirrhosis (UI: D008103, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); Middle Aged (UI: D008875, Major: No); Neoplasm Metastasis (UI: D009362, Major: No); Peritoneal Neoplasms (UI: D010534, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No)

||diagnosis (0)|diagnosis (0)|||complications (0)||methods (0)|diagnosis (0)|||diagnosis (0)

0|0|0|0|1|0|0|0|1|0|0|0|0

null

1978-07-15

2006-11-15

pubmed: 1978-3-1; medline: 1978-3-1 0:1; entrez: 1978-3-1 0:0

pubmed: 26256

Breast Neoplasms

['Neoplasm Metastasis']

26,872

1

Variable content of histaminase, L-dopa decarboxylase and calcitonin in small-cell carcinoma of the lung. Biologic and clinical implications.

MEDLINE

Manual

NLM

To ascertain whether the content of endocrine markers is constant in small-cell carcinoma of the lung, levels of three markers of medullary thyroid carcinoma were studied in this tumor. Histaminase was increased in six of six primary tumors (three to 14,000 times), L-dopa decarboxylase in four of six (six to 30 times), and calcitonin in one of one (eight times) over levels in adjacent lung. Marker levels in mediastinal metastases reflected those in primary tumors in four of five patients. However, in four of seven, multiple hepatic metastases contained low to absent levels despite simultaneously high values in chest lesions. Immunohistochemical studies of histaminase revealed that within each primary tumor different cells contained different amounts of the enzyme. Since marker content varied between tumor cells, between primary tumors and between metastases in individual patients we conclude that circulating levels of these three markers cannot be expected necessarily to mirror tumor burden in patients with small-cell lung tumors.

The New England journal of medicine

0028-4793

Print

299

3

Print

1,978

Jul

20

105-10

S B Baylin (SB); W R Weisburger (WR); J C Eggleston (JC); G Mendelsohn (G); M A Beaven (MA); M D Abeloff (MD); D S Ettinger (DS)

Journal Article (D016428); Research Support, U.S. Gov't, P.H.S. (D013487)

Levodopa (Registry: 46627O600J, UI: D007980); Calcitonin (Registry: 9007-12-9, UI: D002116); Amine Oxidase (Copper-Containing) (Registry: EC 1.4.3.21, UI: D006631); Dopa Decarboxylase (Registry: EC 4.1.1.-, UI: D004296)

APUD Cells (UI: D001078, Major: No) - Qualifiers: analysis (UI: Q000032, Major: No); Amine Oxidase (Copper-Containing) (UI: D006631, Major: No) - Qualifiers: analysis (UI: Q000032, Major: Yes); blood (UI: Q000097, Major: No); Calcitonin (UI: D002116, Major: No) - Qualifiers: analysis (UI: Q000032, Major: Yes); Carcinoma, Small Cell (UI: D018288, Major: No) - Qualifiers: analysis (UI: Q000032, Major: Yes); enzymology (UI: Q000201, Major: No); Dopa Decarboxylase (UI: D004296, Major: No) - Qualifiers: analysis (UI: Q000032, Major: Yes); Humans (UI: D006801, Major: No); Levodopa (UI: D007980, Major: No); Liver Neoplasms (UI: D008113, Major: No) - Qualifiers: analysis (UI: Q000032, Major: No); enzymology (UI: Q000201, Major: No); Lung (UI: D008168, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: No); Lung Neoplasms (UI: D008175, Major: No) - Qualifiers: analysis (UI: Q000032, Major: Yes); enzymology (UI: Q000201, Major: No); Neoplasm Metastasis (UI: D009362, Major: No)

analysis (0)|analysis (1); blood (0)|analysis (1)|analysis (1); enzymology (0)|analysis (1)|||analysis (0); enzymology (0)|enzymology (0)|analysis (1); enzymology (0)|

0|0|0|0|0|0|0|0|0|0|0

null

1978-08-28

2013-11-21

pubmed: 1978-7-20; medline: 1978-7-20 0:1; entrez: 1978-7-20 0:0

pubmed: 26872; doi: 10.1056/NEJM197807202990301

Breast Neoplasms

['Neoplasm Metastasis']

29,706

1

Estradiol receptor analysis in human breast cancer tissue by isoelectric focusing in polyacrylamide gel.

MEDLINE

Manual

NLM

Isoelectric focusing in polyacrylamide gel combined with limited proteolysis is a simple and specific method for quantitation of estradiol receptors in breast cancer tissue. At least eight different samples can be analyzed simultaneously on one gel, and the whole procedure, including sample preparation, takes less than 7 hr. In comparison with sucrose gradient centrifugation, isoelectric focusing is more sensitive, possibly due to the short time (1.5 to 2 hr) needed for the analysis. Furthermore, only one incubation with tritium-labeled estradiol is needed for an analysis, which means that a smaller amount of tumor tissue is needed than for most other methods. This fact allows analysis of the estrogen receptor content in tumor material obtained from fine-needle biopsy.

Cancer research

0008-5472

Print

38

11 Pt 2

Print

1,978

Nov

null

4225-8

J A Gustafsson (JA); S A Gustafsson (SA); B Nordenskjöld (B); S Okret (S); C Silfverswärd (C); O Wrange (O)

Comparative Study (D003160); Journal Article (D016428)

Receptors, Estrogen (Registry: 0, UI: D011960); Estradiol (Registry: 4TI98Z838E, UI: D004958); Trypsin (Registry: EC 3.4.21.4, UI: D014357)

Breast Neoplasms (UI: D001943, Major: No) - Qualifiers: analysis (UI: Q000032, Major: Yes); Centrifugation, Density Gradient (UI: D002499, Major: No); Electrophoresis, Polyacrylamide Gel (UI: D004591, Major: No); Estradiol (UI: D004958, Major: No); Female (UI: D005260, Major: No); Humans (UI: D006801, Major: No); Hydrogen-Ion Concentration (UI: D006863, Major: No); Isoelectric Focusing (UI: D007525, Major: No); Neoplasms, Hormone-Dependent (UI: D009376, Major: No) - Qualifiers: analysis (UI: Q000032, Major: Yes); Receptors, Estrogen (UI: D011960, Major: No) - Qualifiers: analysis (UI: Q000032, Major: Yes); Trypsin (UI: D014357, Major: No)

analysis (1)||||||||analysis (1)|analysis (1)|

0|0|0|0|0|0|0|0|0|0|0

null

1978-12-27

2013-11-21

pubmed: 1978-11-1; medline: 1978-11-1 0:1; entrez: 1978-11-1 0:0

pubmed: 29706

Breast Neoplasms

[]

29,794

1

Carcinoma in situ cervicis uteri: diagnosis, treatment and prognosis.

MEDLINE

Manual

NLM

A total of 252 patients with carcinoma in situ colli uteri were treated at the Women's Clinic at Turku University between 1964 and 1971. Seventy-seven percent of the patients came to the clinic for treatment after they had participated in a mass screening program (cytodiagnosis, colposcopy). Extrafascial hysterectomy was performed most often on women in the older age groups, while most of the younger patients were treated by conization. Patients were followed up for a minimum of 5 years. There was a 1.0% recurrence of invasive carcinoma and a 4.0% recurrence of noninvasive carcinoma. All invasive recurrences occurred after hysterectomy. None of the patients died from complications of carcinoma.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

0020-7292

Print

15

6

Print

1,978

null

494-6

P Liukko (P); R Punnonen (R); M Grönroos (M)

Journal Article (D016428)

null

Adult (UI: D000328, Major: No); Aged (UI: D000368, Major: No); Carcinoma in Situ (UI: D002278, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); radiotherapy (UI: Q000532, Major: No); surgery (UI: Q000601, Major: Yes); Colposcopy (UI: D003127, Major: No); Female (UI: D005260, Major: No); Follow-Up Studies (UI: D005500, Major: No); Humans (UI: D006801, Major: No); Hysterectomy (UI: D007044, Major: No); Middle Aged (UI: D008875, Major: No); Neoplasm Invasiveness (UI: D009361, Major: No); Neoplasm Recurrence, Local (UI: D009364, Major: No); Prognosis (UI: D011379, Major: No); Uterine Cervical Dysplasia (UI: D002578, Major: No) - Qualifiers: surgery (UI: Q000601, Major: No); Uterine Cervical Neoplasms (UI: D002583, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); radiotherapy (UI: Q000532, Major: No); surgery (UI: Q000601, Major: Yes); Vaginal Smears (UI: D014626, Major: No)

||diagnosis (0); radiotherapy (0); surgery (1)||||||||||surgery (0)|diagnosis (0); radiotherapy (0); surgery (1)|

0|0|0|0|0|0|0|0|0|0|0|0|0|0|0

null

1978-12-29

2019-08-19

pubmed: 1978-1-1; medline: 1978-1-1 0:1; entrez: 1978-1-1 0:0

pubmed: 29794; doi: 10.1002/j.1879-3479.1977.tb00740.x

Breast Neoplasms

['Neoplasm Recurrence, Local']

30,326

1

[Application of laser rays in surgery (author's transl)].

MEDLINE

Manual

NLM

Some years will have to pass, until there will be evidence, if application of leaser beam in surgery of Breastcancer, Melanomas or Basaliomas was justified and whether it is possible or not to interrupt or reduce intraoperative tumor cellspread. As an increasing number of surgeons have started to use laser rays in these illnesses, result of laser surgery and those of traditional methods could be compared in a couple of years. Possibly other indications will be outlined in general surgery for the use of laser beside those we have been working out. It may happen that surgeons working with laser beam might bring the method into discredit putting indication not rigorous enough. I should like to remind everybody who starts working with laser rays, to do so with greatest possible care. Collaboration with a technician is recommended. Periodic he should control the machine and handle arising technical problems.

Aktuelle Gerontologie

0300-5704

Print

8

9

Print

1,978

Sep

null

475-9

H Günter (H); W Korab (W); P Kyrle (P)

English Abstract (D004740); Journal Article (D016428)

null

Age Factors (UI: D000367, Major: No); Aged (UI: D000368, Major: No); Breast Neoplasms (UI: D001943, Major: No) - Qualifiers: surgery (UI: Q000601, Major: No); Carcinoma, Basal Cell (UI: D002280, Major: No) - Qualifiers: surgery (UI: Q000601, Major: No); Female (UI: D005260, Major: No); Humans (UI: D006801, Major: No); Laser Therapy (UI: D053685, Major: Yes); Male (UI: D008297, Major: No); Melanoma (UI: D008545, Major: No) - Qualifiers: surgery (UI: Q000601, Major: No); Middle Aged (UI: D008875, Major: No); Surgical Procedures, Operative (UI: D013514, Major: Yes)

||surgery (0)|surgery (0)|||||surgery (0)||

0|0|0|0|0|0|1|0|0|0|1

null

1978-12-20

2007-11-15

pubmed: 1978-9-1; medline: 1978-9-1 0:1; entrez: 1978-9-1 0:0

pubmed: 30326

Breast Neoplasms

[]

30,426

1

Neuroleptic-induced prolactin level elevation and breast cancer: an emerging clinical issue.

MEDLINE

Manual

NLM

This article reviews the evidence that neuroleptics may increase the risk of breast cancer via their effects on prolactin secretion. All available neuroleptics, including reserpine, raise serum prolactin levels. Elevated serum prolactin level increases the incidence of spontaneously occurring mammary tumors in mice, and increases the growth of established carcinogen-induced mammary tumors in rats. Caution is necessary in extrapolating this relationship to human mammary tumors because human and rodent tumors differ in some important characteristics, including hormone responsiveness. Serum prolactin levels in women with, or at risk for, breast cancer have generally been normal, and only a minority of human mammary tumors respond to changes in serum prolactin levels. Epidemiologic studies have failed to demonstrate an increased risk of breast cancer associated with the use of neuroleptics or reserpine. Thus, although some human mammary tumors are prolactin dependent, the available evidence does not demonstrate an increased risk of breast cancer in women receiving neuroleptics. We conclude that (1) additional epidemiologic studies of the incidence of mammary tumors in women treated with neuroleptics are desirable; (2) it is premature to mandate warning patients of an unknown and undemonstrated increase in the risk of developing breast cancer associated with neuroleptic treatment; (3) detection of existing mammary tumors by breast examination prior to administration of neuroleptics is desirable; and (4) development of antipsychotic drugs that do not increase serum prolactin level may be indicated.

Archives of general psychiatry

0003-990X

Print

35

11

Print

1,978

Nov

null

1291-1301

P M Schyve (PM); F Smithline (F); H Y Meltzer (HY)

Journal Article (D016428); Research Support, U.S. Gov't, P.H.S. (D013487)

Antipsychotic Agents (Registry: 0, UI: D014150); Secologanin Tryptamine Alkaloids (Registry: 0, UI: D046948); Reserpine (Registry: 8B1QWR724A, UI: D012110); Prolactin (Registry: 9002-62-4, UI: D011388)

Animals (UI: D000818, Major: No); Antipsychotic Agents (UI: D014150, Major: No) - Qualifiers: adverse effects (UI: Q000009, Major: Yes); Breast Neoplasms (UI: D001943, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); chemically induced (UI: Q000139, Major: Yes); mortality (UI: Q000401, Major: No); Female (UI: D005260, Major: No); Hospitals, Psychiatric (UI: D006778, Major: No); Humans (UI: D006801, Major: No); Male (UI: D008297, Major: No); Mammary Neoplasms, Experimental (UI: D008325, Major: No) - Qualifiers: chemically induced (UI: Q000139, Major: No); Mice (UI: D051379, Major: No); Prolactin (UI: D011388, Major: No) - Qualifiers: blood (UI: Q000097, Major: Yes); Rats (UI: D051381, Major: No); Reserpine (UI: D012110, Major: No) - Qualifiers: adverse effects (UI: Q000009, Major: No); Risk (UI: D012306, Major: No); Schizophrenia (UI: D012559, Major: No) - Qualifiers: drug therapy (UI: Q000188, Major: No); mortality (UI: Q000401, Major: No); Secologanin Tryptamine Alkaloids (UI: D046948, Major: No) - Qualifiers: adverse effects (UI: Q000009, Major: No)

|adverse effects (1)|blood (0); chemically induced (1); mortality (0)|||||chemically induced (0)||blood (1)||adverse effects (0)||drug therapy (0); mortality (0)|adverse effects (0)

0|0|0|0|0|0|0|0|0|0|0|0|0|0|0

null

1978-12-27

2019-07-17

pubmed: 1978-11-1; medline: 1978-11-1 0:1; entrez: 1978-11-1 0:0

pubmed: 30426; doi: 10.1001/archpsyc.1978.01770350017001

Breast Neoplasms

[]

31,810

1

[Precancerous skin lesions in the aged (author's transl)].

MEDLINE

Manual

NLM

The term ""precancerous"" needs a new definition since it includes still malignant diseases like Morbus Paget of the nipple, Morbus Bowen and Erythroplasie Queyrat. The degree of malignancy of these disorders is analyzed. Precancerous conditions in the sense of benignant disorders which necessarily develop into malignant tumors are Melanosis circumscripta praeblastomatosa Dubreuilh and actinic keratoses. Potential precanceroses may be X-ray-atrophy, Leukoplakia and oral papillomatosis. Some actinic, chemic and cytostatic cancerogens are mentioned. Reference is made to the diagnosis, differential diagnosis, prognosis and treatment of precancerous skin lesions. The problem of potential malignancy of nevi is considered in detail. Prevention of cancer needs regular careful clinical control of skin and mucous membranes at least after the 50th year of life.

Aktuelle Gerontologie

0300-5704

Print

8

11

Print

1,978

Nov

null

569-78

A Luger (A)

English Abstract (D004740); Journal Article (D016428)

null

Age Factors (UI: D000367, Major: No); Aged (UI: D000368, Major: No); Bowen's Disease (UI: D001913, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); Erythroplasia (UI: D004919, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); Female (UI: D005260, Major: No); Humans (UI: D006801, Major: No); Leukoplakia (UI: D007971, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); Male (UI: D008297, Major: No); Middle Aged (UI: D008875, Major: No); Paget's Disease, Mammary (UI: D010144, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); Precancerous Conditions (UI: D011230, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: Yes); therapy (UI: Q000628, Major: No); Skin Neoplasms (UI: D012878, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: Yes); therapy (UI: Q000628, Major: No); Terminology as Topic (UI: D009626, Major: No)

||diagnosis (0)|diagnosis (0)|||diagnosis (0)|||diagnosis (0)|diagnosis (1); therapy (0)|diagnosis (1); therapy (0)|

0|0|0|0|0|0|0|0|0|0|0|0|0

null

1979-02-12

2007-11-15

pubmed: 1978-11-1; medline: 1978-11-1 0:1; entrez: 1978-11-1 0:0

pubmed: 31810

Breast Neoplasms

["Paget's Disease, Mammary"]

32,148

1

Adverse effects in maintenance therapy.

MEDLINE

Manual

NLM

Adverse effects in maintenance therapy with neuroleptic drugs and lithium salts were reviewed with special emphasis on tardive dyskinesia. The possible teratogenicity of neuroleptics and lithium salts was discussed and the chromosomal abnormalities seen in patients treated with lithium salts described.

International pharmacopsychiatry

0020-8272

Print

13

4

Print

1,978

null

217-29

T A Ban (TA)

Journal Article (D016428); Review (D016454)

Antipsychotic Agents (Registry: 0, UI: D014150); Mutagens (Registry: 0, UI: D009153); Teratogens (Registry: 0, UI: D013723); Lithium (Registry: 9FN79X2M3F, UI: D008094)

Antipsychotic Agents (UI: D014150, Major: No) - Qualifiers: adverse effects (UI: Q000009, Major: Yes); Bone Diseases (UI: D001847, Major: No) - Qualifiers: chemically induced (UI: Q000139, Major: No); Brain Diseases (UI: D001927, Major: No) - Qualifiers: chemically induced (UI: Q000139, Major: No); Breast Neoplasms (UI: D001943, Major: No) - Qualifiers: chemically induced (UI: Q000139, Major: No); Chronic Disease (UI: D002908, Major: No); Dyskinesia, Drug-Induced (UI: D004409, Major: No) - Qualifiers: etiology (UI: Q000209, Major: No); Eye Manifestations (UI: D005132, Major: No); Humans (UI: D006801, Major: No); Lithium (UI: D008094, Major: No) - Qualifiers: adverse effects (UI: Q000009, Major: Yes); Mental Disorders (UI: D001523, Major: No) - Qualifiers: drug therapy (UI: Q000188, Major: Yes); Mutagens (UI: D009153, Major: No); Skin Pigmentation (UI: D012880, Major: No) - Qualifiers: drug effects (UI: Q000187, Major: No); Teratogens (UI: D013723, Major: No)

adverse effects (1)|chemically induced (0)|chemically induced (0)|chemically induced (0)||etiology (0)|||adverse effects (1)|drug therapy (1)||drug effects (0)|

0|0|0|0|0|0|0|0|0|0|0|0|0

null

1979-03-28

2019-10-27

pubmed: 1978-1-1; medline: 1978-1-1 0:1; entrez: 1978-1-1 0:0

pubmed: 32148; doi: 10.1159/000468343

Breast Neoplasms

[]

32,934

1

The assessment of antichymotrypsin in cancer monitoring.

MEDLINE

Manual

NLM

A comparative study of serum antichymotrypsin, acid glycoprotein and antitrypsin levels has been made in various cancers. Antichymotrypsin (ACT) shows a non-specific elevation in metastatic cancer, and the response reflects tumour progression in a similar fashion to the other two acute phase reactant proteins. The main advantage of ACT as a marker appears to be its Normal distribution in health, and lack of phenotypic variation.

Biomedicine / [publiee pour l'A.A.I.C.I.G.]

0300-0893

Print

28

4

Print

null

209-15

U L Kelly (UL); E H Cooper (EH); C Alexander (C); J Stone (J)

Comparative Study (D003160); Journal Article (D016428)

Carcinoembryonic Antigen (Registry: 0, UI: D002272); Orosomucoid (Registry: 0, UI: D009961); alpha 1-Antitrypsin (Registry: 0, UI: D000515); gamma-Glutamyltransferase (Registry: EC 2.3.2.2, UI: D005723); Alkaline Phosphatase (Registry: EC 3.1.3.1, UI: D000469); Chymotrypsin (Registry: EC 3.4.21.1, UI: D002918)

Alkaline Phosphatase (UI: D000469, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Carcinoembryonic Antigen (UI: D002272, Major: No) - Qualifiers: analysis (UI: Q000032, Major: No); Chymotrypsin (UI: D002918, Major: No) - Qualifiers: antagonists & inhibitors (UI: Q000037, Major: Yes); Female (UI: D005260, Major: No); Gastrointestinal Neoplasms (UI: D005770, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Humans (UI: D006801, Major: No); Male (UI: D008297, Major: No); Neoplasm Metastasis (UI: D009362, Major: No); Neoplasms (UI: D009369, Major: No) - Qualifiers: blood (UI: Q000097, Major: Yes); Orosomucoid (UI: D009961, Major: No) - Qualifiers: analysis (UI: Q000032, Major: No); Pregnancy (UI: D011247, Major: No); alpha 1-Antitrypsin (UI: D000515, Major: No) - Qualifiers: analysis (UI: Q000032, Major: No); gamma-Glutamyltransferase (UI: D005723, Major: No) - Qualifiers: blood (UI: Q000097, Major: No)

blood (0)|analysis (0)|antagonists & inhibitors (1)||blood (0)||||blood (1)|analysis (0)||analysis (0)|blood (0)

0|0|0|0|0|0|0|0|0|0|0|0|0

null

1979-04-26

2006-11-15

pubmed: 1978-7-1; medline: 1978-7-1 0:1; entrez: 1978-7-1 0:0

pubmed: 32934

Breast Neoplasms

['Neoplasm Metastasis']

33,079

1

The effectiveness of obligatory lymphadenectomy in treating carcinoma of the cervix.

MEDLINE

Manual

NLM

For the past 20 years, obligatory lymphadenectomy has been performed with the Wertheim's operation for carcinoma of the cervix at the First University Women's Clinic in Vienna. Formerly, selective lymphadenectomy was performed with the radical operation, with only nodes suspected of metastasis being removed. The theoretical advantages and disadvantages of each system are discussed, and several previous reports are analyzed and criticized. Our experience at the First University Women's Clinic shows that rates of mortality from recurrence were higher for a group of patients who underwent selective lymphadenectomy from 1946 to 1949 than for two more recent series who were treated with obligatory lymphadenectomy. Thus, the effectiveness of performing the latter procedure with the Wertheim's operation to reduce mortality from recurrence is confirmed.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

0020-7292

Print

16

3

Print

null

197-203

H Tulzer (H); S Kupka (S)

Journal Article (D016428)

null

Austria (UI: D001317, Major: No); Female (UI: D005260, Major: No); Humans (UI: D006801, Major: No); Hysterectomy (UI: D007044, Major: Yes); Lymph Node Excision (UI: D008197, Major: Yes); Lymphatic Metastasis (UI: D008207, Major: No); Neoplasm Recurrence, Local (UI: D009364, Major: No) - Qualifiers: mortality (UI: Q000401, Major: No); Uterine Cervical Neoplasms (UI: D002583, Major: No) - Qualifiers: mortality (UI: Q000401, Major: No); surgery (UI: Q000601, Major: Yes)

||||||mortality (0)|mortality (0); surgery (1)

0|0|0|1|1|0|0|0

null

1979-04-25

2019-08-19

pubmed: 1978-1-1; medline: 1978-1-1 0:1; entrez: 1978-1-1 0:0

pubmed: 33079; doi: 10.1002/j.1879-3479.1978.tb00428.x

Breast Neoplasms

['Neoplasm Recurrence, Local']

33,077

1

Repeat laparotomy as a preclinical diagnostic and therapeutic method for treating ovarian carcinoma.

MEDLINE

Manual

NLM

One hundred forty-two cases of epithelial ovarian carcinoma were treated from 1972 to 1976 in the Department of Obstetrics and Gynaecology, University Central Hospital, Turku, Finland. Repeat laparotomy was performed on 37 of the patients about six months after total extirpative surgery (group I). In addition, a second laparotomy was performed on 14 patients after partial surgery or exploratory laparotomy (group II). All patients were given external radiation therapy combined with cytostatic treatment prior to the repeat laparotomies. A preclinical carcinoma was detected in six of the 37 patients in group I. Two of them are asymptomatic after five years of follow-up. In group II, total surgery after initial partial or exploratory laparotomy succeeded in half of the cases. Serous and endometroid carcinomas appeared to respond best to conservative therapy preceding repeat laparotomy.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

0020-7292

Print

16

3

Print

null

190-3

M Grönroos (M); R Punnonen (R); P Liukko (P)

Journal Article (D016428)

null

Female (UI: D005260, Major: No); Finland (UI: D005387, Major: No); Follow-Up Studies (UI: D005500, Major: No); Humans (UI: D006801, Major: No); Laparotomy (UI: D007813, Major: Yes); Neoplasm Metastasis (UI: D009362, Major: No); Ovarian Neoplasms (UI: D010051, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); pathology (UI: Q000473, Major: No); surgery (UI: Q000601, Major: Yes); Ovary (UI: D010053, Major: No) - Qualifiers: surgery (UI: Q000601, Major: Yes)

||||||diagnosis (0); pathology (0); surgery (1)|surgery (1)

0|0|0|0|1|0|0|0

null

1979-04-25

2019-08-19

pubmed: 1978-1-1; medline: 1978-1-1 0:1; entrez: 1978-1-1 0:0

pubmed: 33077; doi: 10.1002/j.1879-3479.1978.tb00426.x

Breast Neoplasms

['Neoplasm Metastasis']

33,399

1

[Clinical study and development of a revealing case of phlebitis].

MEDLINE

Manual

NLM

This article deals with a case of pleural metastases of an adenocarcinoma starting at an unknown point in a 59-year-old patient without notable circulatory antecedents, shown by a recurrent phlebitis having several sites over two months and a hemothorax.

Phlebologie

0031-8280

Print

31

4

Print

null

307-12

G Barkatz (G)

Case Reports (D002363); English Abstract (D004740); Journal Article (D016428)

null

Adenocarcinoma (UI: D000230, Major: No) - Qualifiers: complications (UI: Q000150, Major: Yes); Female (UI: D005260, Major: No); Gout (UI: D006073, Major: No) - Qualifiers: complications (UI: Q000150, Major: No); Heart Diseases (UI: D006331, Major: No) - Qualifiers: complications (UI: Q000150, Major: No); Hematologic Diseases (UI: D006402, Major: No) - Qualifiers: complications (UI: Q000150, Major: No); Humans (UI: D006801, Major: No); Middle Aged (UI: D008875, Major: No); Neoplasm Metastasis (UI: D009362, Major: No); Phlebitis (UI: D010689, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); etiology (UI: Q000209, Major: Yes); Pleural Neoplasms (UI: D010997, Major: No) - Qualifiers: complications (UI: Q000150, Major: Yes); Polyarteritis Nodosa (UI: D010488, Major: No) - Qualifiers: complications (UI: Q000150, Major: No)

complications (1)||complications (0)|complications (0)|complications (0)||||diagnosis (0); etiology (1)|complications (1)|complications (0)

0|0|0|0|0|0|0|0|0|0|0

null

1979-04-25

2006-11-15

pubmed: 1978-10-1; medline: 1978-10-1 0:1; entrez: 1978-10-1 0:0

pubmed: 33399

Breast Neoplasms

['Neoplasm Metastasis']

33,572

1

[New aspects pertaining to the Surgical Treatment of genital cancer in elderly women (author's transl)].

MEDLINE

Manual

NLM

Between 1960 and 1969, 7150 major operations have been performed in the gynecological departements of West-Berlin on female patients of 60 years of age or more. Of 6658 cases the case-history was at our disposal. In contrast to reports in literature, the largest group was that of 3111 malignant tumors (46.7%). The postoperative mortality of the entire group was 7.7%, in cases of malignant tumors 12.1%. Discussion on surgical methods for the most frequent gynecological malignomas, and on possibilities to reduce the postoperative mortality, as well as on some aspects pertaining to the gynecological geroprophylaxis.

Aktuelle Gerontologie

0300-5704

Print

9

2

Print

1,979

Feb

null

59-65

V Jaluvka (V)

English Abstract (D004740); Journal Article (D016428)

null

Age Factors (UI: D000367, Major: No); Aged (UI: D000368, Major: No); Breast Neoplasms (UI: D001943, Major: No) - Qualifiers: surgery (UI: Q000601, Major: No); Female (UI: D005260, Major: No); Genital Neoplasms, Female (UI: D005833, Major: No) - Qualifiers: mortality (UI: Q000401, Major: No); prevention & control (UI: Q000517, Major: No); surgery (UI: Q000601, Major: Yes); Humans (UI: D006801, Major: No); Methods (UI: D008722, Major: No); Middle Aged (UI: D008875, Major: No); Postoperative Complications (UI: D011183, Major: No) - Qualifiers: mortality (UI: Q000401, Major: No); Retrospective Studies (UI: D012189, Major: No); Uterine Neoplasms (UI: D014594, Major: No) - Qualifiers: surgery (UI: Q000601, Major: No)

||surgery (0)||mortality (0); prevention & control (0); surgery (1)||||mortality (0)||surgery (0)

0|0|0|0|0|0|0|0|0|0|0

null

1979-04-25

2006-11-15

pubmed: 1979-2-1; medline: 1979-2-1 0:1; entrez: 1979-2-1 0:0

pubmed: 33572

Breast Neoplasms

[]

33,573

1

[Diagnosis of breast cancer by contact thermography (author's transl)].

MEDLINE

Manual

NLM

Epidemiological studies performed in cooperation with the Austrian National Institute for Statistic show an increase of breast cancer in the age-group of women older than 50 years. Especially in this age-group screening for breast cancer is very important and successful. Mammography in this age-group is the most useful and accurate method. In the group of women aged less than 50 years and particularly less than 45 years the use of mammography for screening is limited because of its risks for the induction of breast cancer in young women. Therefore the combination of clinical examination and contact-thermography is a very promising alternative for the detection of breast cancer. In 133 cases of histologically proved breast cancer the high accuracy of this combination of clinical examination and contact-thermography in comparison with mammography is shown. Based on this good results a recommendation for a detection-scheme for breast cancer with a reduction of radiation exposure in young women by the use of contact-thermography is presented and discussed.

Aktuelle Gerontologie

0300-5704

Print

9

2

Print

1,979

Feb

null

67-74

H Kucera (H); E Kubista (E)

Journal Article (D016428)

null

Adult (UI: D000328, Major: No); Age Factors (UI: D000367, Major: No); Aged (UI: D000368, Major: No); Austria (UI: D001317, Major: No); Breast Neoplasms (UI: D001943, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: Yes); diagnostic imaging (UI: Q000000981, Major: No); epidemiology (UI: Q000453, Major: No); prevention & control (UI: Q000517, Major: No); Female (UI: D005260, Major: No); Humans (UI: D006801, Major: No); Mammography (UI: D008327, Major: No); Middle Aged (UI: D008875, Major: No); Thermography (UI: D013817, Major: No) - Qualifiers: methods (UI: Q000379, Major: Yes)

||||diagnosis (1); diagnostic imaging (0); epidemiology (0); prevention & control (0)|||||methods (1)

0|0|0|0|0|0|0|0|0|0

null

1979-04-25

2016-11-23

pubmed: 1979-2-1; medline: 1979-2-1 0:1; entrez: 1979-2-1 0:0

pubmed: 33573

Breast Neoplasms

[]

35,434

1

Serum levels of pancreatic polypeptide in Zollinger-Ellison syndrome, and hyperparthyroidism from families with multiple endocrine adenomatosis type I.

MEDLINE

Manual

NLM

Mean fasting levels of pancreatic polypeptide (PP) in 24 patients with Zollinger-Ellison syndrome (ZES) and in 12 patients with hyperparathyroidism originating from families with multiple endocrine adenomatosis type I (MEAI-HPT) were significantly higher than in 72 normal controls. The overlap between the 3 groups, however, was large. In patients with ZES, increased PP levels were not related to the presence of MEAI or metastases; nor was there a correlation between serum PP and gastrin concentrations. The post-prandial PP release in 10 ZES patients and in 10 patients with MEAI-HPT was lower than in 9 normal controls. The physiological significance of the present findings is unclear.

Digestion

0012-2823

Print

18

5-6

Print

1,978

null

297-302

C B Lamers (CB); J Diemel (J); W Roeffen (W)

Journal Article (D016428)

Gastrins (Registry: 0, UI: D005755); Pancreatic Polypeptide (Registry: 59763-91-6, UI: D010191)

Adolescent (UI: D000293, Major: No); Adult (UI: D000328, Major: No); Aged (UI: D000368, Major: No); Fasting (UI: D005215, Major: No); Female (UI: D005260, Major: No); Gastrins (UI: D005755, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Humans (UI: D006801, Major: No); Hyperparathyroidism (UI: D006961, Major: No) - Qualifiers: blood (UI: Q000097, Major: Yes); genetics (UI: Q000235, Major: No); Male (UI: D008297, Major: No); Middle Aged (UI: D008875, Major: No); Multiple Endocrine Neoplasia (UI: D009377, Major: No) - Qualifiers: genetics (UI: Q000235, Major: Yes); Neoplasm Metastasis (UI: D009362, Major: No); Pancreatic Polypeptide (UI: D010191, Major: No) - Qualifiers: blood (UI: Q000097, Major: Yes); metabolism (UI: Q000378, Major: No); Zollinger-Ellison Syndrome (UI: D015043, Major: No) - Qualifiers: blood (UI: Q000097, Major: Yes)

|||||blood (0)||blood (1); genetics (0)|||genetics (1)||blood (1); metabolism (0)|blood (1)

0|0|0|0|0|0|0|0|0|0|0|0|0|0

null

1979-07-25

2018-11-30

pubmed: 1978-1-1; medline: 1978-1-1 0:1; entrez: 1978-1-1 0:0

pubmed: 35434; doi: 10.1159/000198216

Breast Neoplasms

['Neoplasm Metastasis']

36,219

1

Serum enzymes in colorectal cancer.

MEDLINE

Manual

NLM

A study of the value of serum enzymes in 184 patients with colorectal cancer has been performed. The enzymes studied were gamma glutamyltransferase (gammaGT), alkaline phosphatase (AP), lactate dehydrogenase (LDH), 5'-nucleotidase (5'-NT), glutathione reductase (GR), alanine and aspartate transaminases. In patients without liver metastases, elevated enzyme levels were found in 11-55% preoperatively. 5'-NT showed the least number of elevated activities, while gammaGT activities were increased in 29% and LDH in 55%. The percentage of elevated enzyme levels rose significantly in the early postoperative period. Patients with liver metastases showed increased enzyme activities in 40-60% preoperatively: gammaGT was the most sensitive indicator. Increased enzyme activity was related to the degree of liver involvement with secondary tumor. With extensive liver metastases, gammaGT levels were increased in 82%. It is concluded that serum enzymes are of limited value in the preoperative detection of liver metastases, and particularly when tumor involvement of the liver is small.

Cancer

0008-543X

Print

43

5

Print

1,979

May

null

1772-6

P R Beck (PR); A Belfield (A); R J Spooner (RJ); L H Blumgart (LH); C B Wood (CB)

Journal Article (D016428)

Enzymes (Registry: 0, UI: D004798); L-Lactate Dehydrogenase (Registry: EC 1.1.1.27, UI: D007770); Glutathione Reductase (Registry: EC 1.8.1.7, UI: D005980); gamma-Glutamyltransferase (Registry: EC 2.3.2.2, UI: D005723); Aspartate Aminotransferases (Registry: EC 2.6.1.1, UI: D001219); Alanine Transaminase (Registry: EC 2.6.1.2, UI: D000410); Alkaline Phosphatase (Registry: EC 3.1.3.1, UI: D000469); N-Glycosyl Hydrolases (Registry: EC 3.2.2.-, UI: D009699)

Alanine Transaminase (UI: D000410, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Alkaline Phosphatase (UI: D000469, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Aspartate Aminotransferases (UI: D001219, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Colonic Neoplasms (UI: D003110, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: Yes); Enzymes (UI: D004798, Major: No) - Qualifiers: blood (UI: Q000097, Major: Yes); Glutathione Reductase (UI: D005980, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Humans (UI: D006801, Major: No); L-Lactate Dehydrogenase (UI: D007770, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Liver Neoplasms (UI: D008113, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); N-Glycosyl Hydrolases (UI: D009699, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Neoplasm Metastasis (UI: D009362, Major: No); Rectal Neoplasms (UI: D012004, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: Yes); gamma-Glutamyltransferase (UI: D005723, Major: No) - Qualifiers: blood (UI: Q000097, Major: No)

blood (0)|blood (0)|blood (0)|enzymology (1)|blood (1)|blood (0)||blood (0)|diagnosis (0)|blood (0)||enzymology (1)|blood (0)

0|0|0|0|0|0|0|0|0|0|0|0|0

null

1979-08-29

2019-06-19

pubmed: 1979-5-1; medline: 1979-5-1 0:1; entrez: 1979-5-1 0:0

pubmed: 36219; doi: 10.1002/1097-0142(197905)43:5<1772::aid-cncr2820430529>3.0.co;2-y

Breast Neoplasms

['Neoplasm Metastasis']

36,671

1

Serum gamma-glutamyl transpeptidase: its specificity and clinical value.

MEDLINE

Manual

NLM

The clinical import of the serum gamma-glutamyl transpeptidase (GGTP) level was evaluted in 162 prospectively studied patients. GGTP is helpful in determining the origin of alkaline phosphatase (AP); it clearly separates increased AP of bone and placental origin from that of liver origin. The GGTP level closely parallels the AP level in most instances, but it may be more sensitive in detecting liver disease in anicteric patients. The finding of significantly increased GGTP in patients with chronic aggressive hepatitis as compared to normal levels found in chronic persistent hepatitis may provide a prognostic clue in cases of unresolved hepatitis. The apparent specificity and sensitivity of the GGTP test, combined with ease of performance and low expense, make it a valuable addition to the evaluation of a patient with hepatic disease.

Southern medical journal

0038-4348

Print

72

7

Print

1,979

Jul

null

837-41

M Levinson (M); J Holbert (J); C Blackwell (C); L D Wruble (LD)

Journal Article (D016428); Research Support, U.S. Gov't, P.H.S. (D013487)

gamma-Glutamyltransferase (Registry: EC 2.3.2.2, UI: D005723); Alkaline Phosphatase (Registry: EC 3.1.3.1, UI: D000469)

Adolescent (UI: D000293, Major: No); Adult (UI: D000328, Major: No); Aged (UI: D000368, Major: No); Alkaline Phosphatase (UI: D000469, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Biliary Tract Diseases (UI: D001660, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: No); Epilepsy (UI: D004827, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: No); Female (UI: D005260, Major: No); Heart Failure (UI: D006333, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: No); Hepatitis (UI: D006505, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: No); Humans (UI: D006801, Major: No); Liver Cirrhosis, Alcoholic (UI: D008104, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: No); Liver Neoplasms (UI: D008113, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: No); Male (UI: D008297, Major: No); Middle Aged (UI: D008875, Major: No); Neoplasm Metastasis (UI: D009362, Major: No); Pregnancy (UI: D011247, Major: No); gamma-Glutamyltransferase (UI: D005723, Major: No) - Qualifiers: blood (UI: Q000097, Major: Yes)

|||blood (0)|enzymology (0)|enzymology (0)||enzymology (0)|enzymology (0)||enzymology (0)|enzymology (0)|||||blood (1)

0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0

null

1979-08-29

2019-07-02

pubmed: 1979-7-1; medline: 1979-7-1 0:1; entrez: 1979-7-1 0:0

pubmed: 36671; doi: 10.1097/00007611-197907000-00021

Breast Neoplasms

['Neoplasm Metastasis']

37,382

1

[On the value of drill biopsy in diagnosis of breast lesions (author's transl)].

MEDLINE

Manual

NLM

During a period of 30 months 216 drill biopsies of palpable breast lesions were carried out. By using this method sufficient tissue material for a histological examination could be acquired in all cases. Out of 106 cases, in which the histological results could exactly be proved by following excision biopsy or mastectomy, 87% were correctly diagnosed by drill biopsy. The reason for failure in all of the 14 false drill biopsy diagnoses was due to sampling error. Comparing the diagnostic results of the first 15 month after establishing the method, with the second half of the investigation period, a considerable improvement from 80% to 94% of correct diagnoses could be established. This improvement was based on increasing experience and routine. By means of drill biopsy, cosmetically and diagnostically disturbing scar formation could be avoided. Drill biopsy can be carried out in local anaesthesia and on outpatient basis as well. It is also suitable for frozen-section technique.

Langenbecks Archiv fur Chirurgie

0023-8236

Print

348

2

Print

1,979

May

2

109-18

A Schöll (A); J Maurath (J); L Addae-Mensah (L)

English Abstract (D004740); Journal Article (D016428)

null

Biopsy, Needle (UI: D001707, Major: No) - Qualifiers: instrumentation (UI: Q000295, Major: No); methods (UI: Q000379, Major: Yes); Breast Diseases (UI: D001941, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: Yes); pathology (UI: Q000473, Major: No); Breast Neoplasms (UI: D001943, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); pathology (UI: Q000473, Major: No); Female (UI: D005260, Major: No); Fibroma (UI: D005350, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); Gynecomastia (UI: D006177, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); Humans (UI: D006801, Major: No); Lipoma (UI: D008067, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); Male (UI: D008297, Major: No); Sclerosis (UI: D012598, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No)

instrumentation (0); methods (1)|diagnosis (1); pathology (0)|diagnosis (0); pathology (0)||diagnosis (0)|diagnosis (0)||diagnosis (0)||diagnosis (0)

0|0|0|0|0|0|0|0|0|0

null

1979-09-25

2019-08-19

pubmed: 1979-5-2; medline: 1979-5-2 0:1; entrez: 1979-5-2 0:0

pubmed: 4361079; doi: 10.1007/BF01239668

Breast Neoplasms

[]

37,546

1

[The determination of phosphohexose isomerase in patients with cancer of breast and uterus. A comparison with other tests (author's transl)].

MEDLINE

Manual

NLM

The levels of PHI are evaluated in 94 patients, who are classified by histological, scintigraphycal, radiological, biochemical and clinical test in: 16 patients, who suffer from some premalignant lesions of breast and uterus, 15 patients, who suffer from cancer of breast without metastases, 20 patients who suffer from cancer of breast with metastases, 18 patients who suffer from with cancer of uterus without metastases, 25 patients who suffer from cancer of uterus with metastases. The PHI activity is also evaluated in relation to the activity of other enzymes (LDH, AIP, G-GT). It has been revealed that: a) the PHI activity keeps within limits of normal value in patients who suffer from some pre-malignant lesions; b) all the patients suffer from cancer of breast without metastases show normal levels of PHI; c) in the patients with cancer of breast with metastases: 5 patients show normal levels of PHI, 5 patients show levels of PHI within limits, certainly 10 patients show pathological levels; d) in patients with cancer of uterus without metastases the value of enzymes results pathological in 6 patients, 6 patients show levels of PHI within limits that are above average and 6 patients show normal levels of PHI; e) the value of PHI always results high in patients with cancer of uterus with metastases.

Quaderni Sclavo di diagnostica clinica e di laboratorio

0033-4979

Print

15

3

Print

1,978

Sep

null

365-72

P Telesforo (P); R Rosenberg (R)

English Abstract (D004740); Journal Article (D016428)

L-Lactate Dehydrogenase (Registry: EC 1.1.1.27, UI: D007770); gamma-Glutamyltransferase (Registry: EC 2.3.2.2, UI: D005723); Alkaline Phosphatase (Registry: EC 3.1.3.1, UI: D000469); Glucose-6-Phosphate Isomerase (Registry: EC 5.3.1.9, UI: D005956)

Alkaline Phosphatase (UI: D000469, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Breast Neoplasms (UI: D001943, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: Yes); Female (UI: D005260, Major: No); Glucose-6-Phosphate Isomerase (UI: D005956, Major: No) - Qualifiers: blood (UI: Q000097, Major: Yes); Humans (UI: D006801, Major: No); L-Lactate Dehydrogenase (UI: D007770, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Neoplasm Metastasis (UI: D009362, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: No); Precancerous Conditions (UI: D011230, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: Yes); Uterine Neoplasms (UI: D014594, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: Yes); gamma-Glutamyltransferase (UI: D005723, Major: No) - Qualifiers: blood (UI: Q000097, Major: No)

blood (0)|enzymology (1)||blood (1)||blood (0)|enzymology (0)|enzymology (1)|enzymology (1)|blood (0)

0|0|0|0|0|0|0|0|0|0

null

1979-09-17

2009-11-11

pubmed: 1978-9-1; medline: 1978-9-1 0:1; entrez: 1978-9-1 0:0

pubmed: 37546

Breast Neoplasms

['Neoplasm Metastasis']

37,654

1

[Clinical chemical parameter changes in patients with liver metastases].

MEDLINE

Manual

NLM

Certain biochemical serum parameters: GOT, GPT, LAP, HK, AP and Regan isoenzyme, GGTP, CE, ESR, Weltman test, thymol test, serum bilirubin and urine urobilogen were determined in 39 patients with different localization of malignant processes in the abdominal cavity (stomach, large intestines, pancreas, ovaries). The patients were subdivided into two groups, depending on the presence or absence of liver metastases, confirmed at laparatomy, laparascopy or necropsy material examination. The results revealed that in patients with liver metastases AP, CE, GOT, GGTP, ESR and Weltman test are most commonly and simultaneously abnormal. In patients without liver metastases, those indices are also changed but to a lesser degree, whereas LAP and Regan isoenyzme are with elevated activity in a higher per cent of these cases, than in the patients with liver metastases, being in unison with literature data. The determination of the above biochemical parameters could direct the clinicist to the presence of liver metastases but the more reliable diagnostic methods as laparascopy and laparatomy cannot be substituted for.

Vutreshni bolesti

0506-2772

Print

18

2

Print

1,979

null

45-50

S Stoĭchev (S); R K'osovska (R); R Khaĭdutova (R); S Dimitrova (S); S Chakurov (S)

English Abstract (D004740); Journal Article (D016428)

Isoenzymes (Registry: 0, UI: D007527); Urobilinogen (Registry: 14684-37-8, UI: D014558); gamma-Glutamyltransferase (Registry: EC 2.3.2.2, UI: D005723); Aspartate Aminotransferases (Registry: EC 2.6.1.1, UI: D001219); Alanine Transaminase (Registry: EC 2.6.1.2, UI: D000410); Hexokinase (Registry: EC 2.7.1.1, UI: D006593); Cholinesterases (Registry: EC 3.1.1.8, UI: D002802); Alkaline Phosphatase (Registry: EC 3.1.3.1, UI: D000469); Leucyl Aminopeptidase (Registry: EC 3.4.11.1, UI: D007931); Bilirubin (Registry: RFM9X3LJ49, UI: D001663)

Alanine Transaminase (UI: D000410, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Alkaline Phosphatase (UI: D000469, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Aspartate Aminotransferases (UI: D001219, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Bilirubin (UI: D001663, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Carcinoma (UI: D002277, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); Cholinesterases (UI: D002802, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Clinical Enzyme Tests (UI: D004796, Major: No); Hexokinase (UI: D006593, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Humans (UI: D006801, Major: No); Isoenzymes (UI: D007527, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Leucyl Aminopeptidase (UI: D007931, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); Liver Neoplasms (UI: D008113, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: Yes); Neoplasm Metastasis (UI: D009362, Major: No); Urobilinogen (UI: D014558, Major: No) - Qualifiers: urine (UI: Q000652, Major: No); gamma-Glutamyltransferase (UI: D005723, Major: No) - Qualifiers: blood (UI: Q000097, Major: No)

blood (0)|blood (0)|blood (0)|blood (0)|diagnosis (0)|blood (0)||blood (0)||blood (0)|blood (0)|diagnosis (1)||urine (0)|blood (0)

0|0|0|0|0|0|0|0|0|0|0|0|0|0|0

null

1979-09-17

2013-11-21

pubmed: 1979-1-1; medline: 1979-1-1 0:1; entrez: 1979-1-1 0:0

pubmed: 37654

Breast Neoplasms

['Neoplasm Metastasis']

37,740

1

The endodermal origin of digestive and respiratory tract APUD cells. Histopathologic evidence and a review of the literature.

MEDLINE

Manual

NLM

Twenty-seven small cell carcinomas of the lung and three tumors of the large intestine with combined adenocarcinomatous and small cell and/or anaplastic carcinoid-type histologic features were studied by light and electron microscopy. It was shown that the small cells have morphologic characteristics of APUD cells. Also presented are the histologic features of a carcinoma of the lung with large cell undifferentiated carcinoma, adenocarcinoma, squamous cell carcinoma, and giant cell carcinoma areas in the primary site and in several metastatic foci. Two of the renal metastases showed small cell carcinoma. The combined tumors and the numerous other similar neoplasms described in the literature and reviewed here suggest an endodermal origin for digestive and respiratory tract APUD cells based on the hypothesis that cancer is a clonal proliferation, and mucous and squamous cell differentiation is an endodermal rather than neural crest characteristic. The ultrastructural features of tumors of cells of known neural crest origin, including a medullary carcinoma of the thyroid, three carotid body tumors, a pheochromocytoma, and two cutaneous melanomas were compared with those of other APUD cell tumors including small cell carcinomas of the lung, two bronchial carcinoids, a carcinoid of the appendix, and a carcinoid of the kidney. Cells of the latter group sometimes possessed cytoplasmic tonofibrils, round compact masses of cytoplasmic microfilaments, and ductal lumina. These features were lacking in the former group and may signify a different embryologic origin. The histologic, histopathologic, and embryologic evidence regarding the origin of digestive and respiratory tract APUD cells is reviewed, showing that the former are, and the latter probably are, of endodermal and not neuroectodermal origin.

The American journal of pathology

0002-9440

Print

96

1

Print

1,979

Jul

null

5-20

G S Sidhu (GS)

Comparative Study (D003160); Journal Article (D016428)

null

APUD Cells (UI: D001078, Major: No) - Qualifiers: ultrastructure (UI: Q000648, Major: Yes); Carcinoma (UI: D002277, Major: No) - Qualifiers: pathology (UI: Q000473, Major: Yes); Carcinoma, Small Cell (UI: D018288, Major: No) - Qualifiers: pathology (UI: Q000473, Major: Yes); Cytoplasmic Granules (UI: D003594, Major: No) - Qualifiers: ultrastructure (UI: Q000648, Major: No); Cytoskeleton (UI: D003599, Major: No) - Qualifiers: ultrastructure (UI: Q000648, Major: No); Humans (UI: D006801, Major: No); Intercellular Junctions (UI: D007365, Major: No) - Qualifiers: ultrastructure (UI: Q000648, Major: No); Intestinal Neoplasms (UI: D007414, Major: No) - Qualifiers: pathology (UI: Q000473, Major: Yes); Intestine, Large (UI: D007420, Major: Yes); Lung Neoplasms (UI: D008175, Major: No) - Qualifiers: pathology (UI: Q000473, Major: Yes); Middle Aged (UI: D008875, Major: No); Neoplasm Metastasis (UI: D009362, Major: No)

ultrastructure (1)|pathology (1)|pathology (1)|ultrastructure (0)|ultrastructure (0)||ultrastructure (0)|pathology (1)||pathology (1)||

0|0|0|0|0|0|0|0|1|0|0|0

null

1979-09-25

2018-11-13

pubmed: 1979-7-1; medline: 1979-7-1 0:1; entrez: 1979-7-1 0:0

pubmed: 956450; pmc: PMC2042351

Breast Neoplasms

['Neoplasm Metastasis']

38,512

1

[Advances on prolactin (author's transl)].

MEDLINE

Manual

NLM

Prolactin has been lately singled-out among the pituitary hormones, and as such the object of considerable research in the past 15 years. The frequency of prolactin secreting adenomes is established now. The responsability of iatrogenic factors (neuroleptics, oral contraceptives) in some hyperprolactineamias is a known fact. The study of the inhibiting dopaminergic system was a landmark in the treatment of hyperprolactinaemia. During the recent Nice Congress, some issues remained unsettled on the physiological activities of prolactin. The matter is clearer when its comes to prolactin secretion. In equilibrium between inhibiting and stimulant factors, the secretion is controlled by the CNS, influenced by the hormonal environment, and its timing is the object of a retrocontrol. This is a very instructive pattern in endocrinology.

La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris

null

55

13-14

Print

null

698-710

J M Segrestaa (JM); J Techenet (J); J Gueris (J); M Lamotte (M)

Journal Article (D016428); Review (D016454)

Antipsychotic Agents (Registry: 0, UI: D014150); Contraceptives, Oral (Registry: 0, UI: D003276); Dopamine Antagonists (Registry: 0, UI: D018492); Gonadotropins (Registry: 0, UI: D006062); Pituitary Hormones, Anterior (Registry: 0, UI: D010908); Sympathomimetics (Registry: 0, UI: D013566); Serotonin (Registry: 333DO1RDJY, UI: D012701); Progesterone (Registry: 4G7DS2Q64Y, UI: D011374); Thyrotropin-Releasing Hormone (Registry: 5Y5F15120W, UI: D013973); Prolactin (Registry: 9002-62-4, UI: D011388); Prolactin Release-Inhibiting Factors (Registry: 9034-47-3, UI: D011389); Dopamine (Registry: VTD58H1Z2X, UI: D004298)

Adrenal Glands (UI: D000311, Major: No) - Qualifiers: drug effects (UI: Q000187, Major: No); Animals (UI: D000818, Major: No); Antipsychotic Agents (UI: D014150, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Breast (UI: D001940, Major: No) - Qualifiers: drug effects (UI: Q000187, Major: No); Breast Neoplasms (UI: D001943, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Carbohydrate Metabolism (UI: D050260, Major: No); Central Nervous System (UI: D002490, Major: No) - Qualifiers: drug effects (UI: Q000187, Major: No); Contraceptives, Oral (UI: D003276, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Dopamine (UI: D004298, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Dopamine Antagonists (UI: D018492, Major: No); Female (UI: D005260, Major: No); Fetus (UI: D005333, Major: No) - Qualifiers: drug effects (UI: Q000187, Major: No); Genitalia, Male (UI: D005837, Major: No) - Qualifiers: drug effects (UI: Q000187, Major: No); Gonadotropins (UI: D006062, Major: No) - Qualifiers: antagonists & inhibitors (UI: Q000037, Major: No); Humans (UI: D006801, Major: No); Male (UI: D008297, Major: No); Ovulation (UI: D010060, Major: No) - Qualifiers: drug effects (UI: Q000187, Major: No); Pituitary Hormones, Anterior (UI: D010908, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Progesterone (UI: D011374, Major: No) - Qualifiers: antagonists & inhibitors (UI: Q000037, Major: No); Prolactin (UI: D011388, Major: No) - Qualifiers: blood (UI: Q000097, Major: No); metabolism (UI: Q000378, Major: Yes); pharmacology (UI: Q000494, Major: No); Prolactin Release-Inhibiting Factors (UI: D011389, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Serotonin (UI: D012701, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Sexual Behavior (UI: D012725, Major: No) - Qualifiers: drug effects (UI: Q000187, Major: No); Sympathomimetics (UI: D013566, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Thyrotropin-Releasing Hormone (UI: D013973, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No); Water-Electrolyte Balance (UI: D014882, Major: No) - Qualifiers: drug effects (UI: Q000187, Major: No)

drug effects (0)||metabolism (0)|drug effects (0)|metabolism (0)||drug effects (0)|metabolism (0)|metabolism (0)|||drug effects (0)|drug effects (0)|antagonists & inhibitors (0)|||drug effects (0)|metabolism (0)|antagonists & inhibitors (0)|blood (0); metabolism (1); pharmacology (0)|metabolism (0)|metabolism (0)|drug effects (0)|metabolism (0)|metabolism (0)|drug effects (0)

0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0

null

1979-10-26

2018-11-30

pubmed: 1979-4-8; medline: 1979-4-8 0:1; entrez: 1979-4-8 0:0

pubmed: 38512

Breast Neoplasms

[]

38,923

1

gamma-Glutamyltransferase in human and mouse breast tumours.

MEDLINE

Manual

NLM

A series of experimental mouse tumours were assayed for their gamma-glutamyltransferase activities. Significantly raised activities were found in a transplantable spontaneous mammary carcinoma compared to normal or lactating mouse breast. A study was therefore undertaken of human breast tumours. Carcinomas showed significantly elevated enzyme levels when compared with normal tissue or histologically uninvolved tissue from a breast containing a carcinoma. Fibroadenoma and chronic mastitis also showed significantly elevated levels when compared with normal tissue and did not differ significantly from carcinoma tissue. Benign breast cyst fluid showed very high levels of enzyme activity. Binding properties of the enzyme to Con A-Sepharose suggested that while normal tissue and fibroadenomas contained only asialated enzyme, carcinomas, chronic mastitis and cyst fluid contained a substantial proportion of sialated enzyme.

Clinica chimica acta; international journal of clinical chemistry

0009-8981

Print

96

1-2

Print

1,979

Aug

15

37-42

J Dawson (J); G D Smith (GD); J Boak (J); T J Peters (TJ)

Comparative Study (D003160); Journal Article (D016428)

gamma-Glutamyltransferase (Registry: EC 2.3.2.2, UI: D005723)

Animals (UI: D000818, Major: No); Breast (UI: D001940, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: No); Breast Neoplasms (UI: D001943, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: Yes); Female (UI: D005260, Major: No); Humans (UI: D006801, Major: No); Mammary Neoplasms, Experimental (UI: D008325, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: Yes); Mice (UI: D051379, Major: No); Species Specificity (UI: D013045, Major: No); gamma-Glutamyltransferase (UI: D005723, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: Yes)

|enzymology (0)|enzymology (1)|||enzymology (1)|||metabolism (1)

0|0|0|0|0|0|0|0|0

null

1979-11-29

2019-07-06

pubmed: 1979-8-15; medline: 1979-8-15 0:1; entrez: 1979-8-15 0:0

pubmed: 38923; pii: 0009-8981(79)90049-4; doi: 10.1016/0009-8981(79)90049-4

Breast Neoplasms

[]

39,811

1

Tumorigenic aspects.

MEDLINE

Manual

NLM

This report presents a review of tumors, except those of pituitary, that have been reported to occur in women taking combined oral contraceptive preparations. Pathologic features, both gross and microscopic, and differential diagnosis are emphasized. Particular attention is given to tumors of the liver: focal nodular hyperplasia (hepatic hamartoma) and liver cell adenoma (benign hepatoma). The characteristic features of these usually distinctive lesions are illustrated, and an attempt is made to evaluate the significance of each with respect to oral contraceptives. Tumorigenic aspects relating to the uterus and the breast are briefly discussed.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

0020-7292

Print

16

6

Print

null

473-8

M E Kirk (ME)

Journal Article (D016428); Review (D016454)

Contraceptives, Oral (Registry: 0, UI: D003276); Contraceptives, Oral, Combined (Registry: 0, UI: D003277); Contraceptives, Oral, Synthetic (Registry: 0, UI: D003280)

Adenofibroma (UI: D000232, Major: No) - Qualifiers: pathology (UI: Q000473, Major: No); Breast Diseases (UI: D001941, Major: No) - Qualifiers: chemically induced (UI: Q000139, Major: No); Breast Neoplasms (UI: D001943, Major: No) - Qualifiers: chemically induced (UI: Q000139, Major: Yes); Carcinoma in Situ (UI: D002278, Major: No) - Qualifiers: chemically induced (UI: Q000139, Major: No); Carcinoma, Hepatocellular (UI: D006528, Major: No) - Qualifiers: chemically induced (UI: Q000139, Major: No); pathology (UI: Q000473, Major: No); Contraceptives, Oral (UI: D003276, Major: No) - Qualifiers: adverse effects (UI: Q000009, Major: Yes); Contraceptives, Oral, Combined (UI: D003277, Major: No) - Qualifiers: adverse effects (UI: Q000009, Major: Yes); Contraceptives, Oral, Synthetic (UI: D003280, Major: No) - Qualifiers: adverse effects (UI: Q000009, Major: Yes); Female (UI: D005260, Major: No); Humans (UI: D006801, Major: No); Hyperplasia (UI: D006965, Major: No); Liver (UI: D008099, Major: No) - Qualifiers: pathology (UI: Q000473, Major: No); Liver Neoplasms (UI: D008113, Major: No) - Qualifiers: chemically induced (UI: Q000139, Major: Yes); pathology (UI: Q000473, Major: No); Precancerous Conditions (UI: D011230, Major: No); Pregnancy (UI: D011247, Major: No); Uterine Cervical Dysplasia (UI: D002578, Major: No) - Qualifiers: chemically induced (UI: Q000139, Major: No); Uterine Cervical Neoplasms (UI: D002583, Major: No) - Qualifiers: chemically induced (UI: Q000139, Major: Yes); Vaginal Smears (UI: D014626, Major: No)

pathology (0)|chemically induced (0)|chemically induced (1)|chemically induced (0)|chemically induced (0); pathology (0)|adverse effects (1)|adverse effects (1)|adverse effects (1)||||pathology (0)|chemically induced (1); pathology (0)|||chemically induced (0)|chemically induced (1)|

0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0|0

null

1979-12-20

2019-08-19

pubmed: 1978-1-1; medline: 1978-1-1 0:1; entrez: 1978-1-1 0:0

pubmed: 39811; doi: 10.1002/j.1879-3479.1979.tb00952.x

Breast Neoplasms

[]

40,687

1

Fine-needle aspiration of the breast: diagnoses and pitfalls. A review of 3545 cases.

MEDLINE

Manual

NLM

Fine-needle aspiration is now a recognized diagnostic tool. In the past eight years we have studied 3545 aspirates from the breast, including both cystic and solid masses. All were prepared according to the method of Papanicalaou. The cellular findings are described and discussed. Abnormal cells were found in the aspirates from 90% of the 368 malignancies. Reliable criteria for diagnosis are emphasized and diagnostic pitfalls discussed. Aspiration biopsy was helpful in the management of all patients with breast lesions. The method is rapid, accurate, and essentially complication-free. It should be used with the idea of complementing, not competing with, routine histologic biopsy.

Cancer

0008-543X

Print

44

4

Print

1,979

Oct

null

1458-64

T S Kline (TS); L P Joshi (LP); H S Neal (HS)

Journal Article (D016428)

null

Adenofibroma (UI: D000232, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); Adult (UI: D000328, Major: No); Aged (UI: D000368, Major: No); Biopsy, Needle (UI: D001707, Major: Yes); Breast Diseases (UI: D001941, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: Yes); Breast Neoplasms (UI: D001943, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: Yes); Carcinoma, Intraductal, Noninfiltrating (UI: D002285, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); False Negative Reactions (UI: D005188, Major: No); False Positive Reactions (UI: D005189, Major: No); Female (UI: D005260, Major: No); Fibrocystic Breast Disease (UI: D005348, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); Gynecomastia (UI: D006177, Major: No) - Qualifiers: diagnosis (UI: Q000175, Major: No); Humans (UI: D006801, Major: No); Male (UI: D008297, Major: No); Middle Aged (UI: D008875, Major: No)

diagnosis (0)||||diagnosis (1)|diagnosis (1)|diagnosis (0)||||diagnosis (0)|diagnosis (0)|||

0|0|0|1|0|0|0|0|0|0|0|0|0|0|0

null

1980-01-19

2019-06-19

pubmed: 1979-10-1; medline: 1979-10-1 0:1; entrez: 1979-10-1 0:0

pubmed: 40687; doi: 10.1002/1097-0142(197910)44:4<1458::aid-cncr2820440440>3.0.co;2-t

Breast Neoplasms

[]

42,210

1

Analysis of mammary tumors for cytochemical evidence of endogenous mammary peroxidase.

MEDLINE

Manual

NLM

The purpose of this study was to determine whether or not endogenous mammary peroxidase can serve as a cytochemical marker to distinguish ovarian hormone-dependent from ovarian hormone independent mammary tumors. Spontaneous mammary tumors arising in virgin C3H and GR mice (hormone independent tumors) and hormone-dependent mammary tumors arising during pregnancy in GR mice were examined. None of these tumors contained mammary peroxidase. Mammary tumors induced in Sprague-Dawley rats with methylnitrousourea (MNU) and dimethylbenzanthracene (DMBA) were also examined. These tumors included hormone-dependent and hormone independent ones. Several of the DMBA-induced hormone-dependent tumors contained a few peroxidase-positive cells, but the hormone independent tumors were negative. All of the MNU-induced tumors examined were negative for mammary peroxidase. Twenty human breast tumors (malignant and non-malignant) removed from women at surgery, were also negative for mammary peroxidase. Our results indicate that endogenous mammary peroxidase cannot be used to distinguish hormone-dependent from hormone independent mammary tumors.

Virchows Archiv. B, Cell pathology including molecular pathology

0340-6075

Print

31

2

Print

1,979

Oct

null

135-42

J M Strum (JM); P J Becci (PJ)

Journal Article (D016428); Research Support, U.S. Gov't, P.H.S. (D013487)

9,10-Dimethyl-1,2-benzanthracene (Registry: 57-97-6, UI: D015127); Methylnitrosourea (Registry: 684-93-5, UI: D008770); Peroxidases (Registry: EC 1.11.1.-, UI: D010544)

9,10-Dimethyl-1,2-benzanthracene (UI: D015127, Major: No); Animals (UI: D000818, Major: No); Breast Neoplasms (UI: D001943, Major: No) - Qualifiers: enzymology (UI: Q000201, Major: No); Female (UI: D005260, Major: No); Humans (UI: D006801, Major: No); Mammary Neoplasms, Experimental (UI: D008325, Major: No) - Qualifiers: chemically induced (UI: Q000139, Major: No); enzymology (UI: Q000201, Major: Yes); Methylnitrosourea (UI: D008770, Major: No); Mice (UI: D051379, Major: No); Peroxidases (UI: D010544, Major: No) - Qualifiers: analysis (UI: Q000032, Major: Yes); Pregnancy (UI: D011247, Major: No); Rats (UI: D051381, Major: No)

||enzymology (0)|||chemically induced (0); enzymology (1)|||analysis (1)||

0|0|0|0|0|0|0|0|0|0|0

null

1980-02-15

2019-09-18

pubmed: 1979-10-1; medline: 1979-10-1 0:1; entrez: 1979-10-1 0:0

pubmed: 42210; doi: 10.1007/BF02889931

Breast Neoplasms

[]

42,555

1

Increased release of tumour cells by collagenase at acid pH: a possible mechanism for metastasis.

MEDLINE

Manual

NLM

The ability of collagenase to disaggregate a solid metastasizing lymphosarcoma has been shown to considerably increase with reducing environmental pH. It is suggested that this effect may be operating in vivo to release cells from a primary tumour.

Experientia

0014-4754

Print

35

12

Print

1,979

Dec

15

1657-8

G A Turner (GA)

Journal Article (D016428)

Microbial Collagenase (Registry: EC 3.4.24.3, UI: D003012)

Animals (UI: D000818, Major: No); Cricetinae (UI: D006224, Major: No); Hydrogen-Ion Concentration (UI: D006863, Major: No); Lymphoma, Non-Hodgkin (UI: D008228, Major: No) - Qualifiers: physiopathology (UI: Q000503, Major: Yes); Mesocricetus (UI: D008647, Major: No); Microbial Collagenase (UI: D003012, Major: Yes); Neoplasm Metastasis (UI: D009362, Major: Yes); Neoplasms, Experimental (UI: D009374, Major: No) - Qualifiers: physiopathology (UI: Q000503, Major: No)

|||physiopathology (1)||||physiopathology (0)

0|0|0|0|0|1|1|0

null

1980-03-17

2019-06-29

pubmed: 1979-12-15; medline: 1979-12-15 0:1; entrez: 1979-12-15 0:0

pubmed: 5924022; doi: 10.1007/BF01953252

Breast Neoplasms

['Neoplasm Metastasis']

42,570

1

Choriocarcinoma associated with thyrotoxicosis: a case report.

MEDLINE

Manual

NLM

A woman with disseminated choriocarcinoma and with clinical and biochemical evidence of thyrotoxicosis is described. Only a few cases have been previously reported, and works are referred to showing that high levels of human chorionic gonadotropin (HCG) probably are responsible for the thyroid-stimulating activity in patients with trophoblastic disease and clinical signs of thyrotoxicosis.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

0020-7292

Print

17

3

Print

null

206-8

K Haram (K); B Klykken (B); E Engebjerg (E)

Case Reports (D002363); Journal Article (D016428)

Chorionic Gonadotropin (Registry: 0, UI: D006063)

Adult (UI: D000328, Major: No); Choriocarcinoma (UI: D002822, Major: No) - Qualifiers: complications (UI: Q000150, Major: Yes); urine (UI: Q000652, Major: No); Chorionic Gonadotropin (UI: D006063, Major: No) - Qualifiers: urine (UI: Q000652, Major: No); Female (UI: D005260, Major: No); Humans (UI: D006801, Major: No); Hyperthyroidism (UI: D006980, Major: No) - Qualifiers: complications (UI: Q000150, Major: Yes); Neoplasm Metastasis (UI: D009362, Major: No); Pregnancy (UI: D011247, Major: No); Uterine Neoplasms (UI: D014594, Major: No) - Qualifiers: complications (UI: Q000150, Major: Yes); urine (UI: Q000652, Major: No)

|complications (1); urine (0)|urine (0)|||complications (1)|||complications (1); urine (0)

0|0|0|0|0|0|0|0|0

null

1980-03-17

2019-08-19

pubmed: 1979-11-1; medline: 1979-11-1 0:1; entrez: 1979-11-1 0:0

pubmed: 42570; doi: 10.1002/j.1879-3479.1979.tb00151.x

Breast Neoplasms

['Neoplasm Metastasis']

42,569

1

Basal cell carcinoma of the vulva.

MEDLINE

Manual

NLM

Basal cell carcinoma was found in eight of 61 cases of vulvar malignancy occurring over a 20-year period. This incidence of basal cell carcinoma was 13.1%, higher than the expected 2%-5% reported previously in the literature. Symptoms of a mass, usually discharge, pruritus or bleeding, were commonly ignored for long periods of time by the elderly patient. The specific location and size were difficult to ascertain from hospital records. Therapy is always surgical with wide local excision recommended. Local recurrence will be noted in 10%-20%, as vulvar basal cell carcinoma is a multicentric lesion and, therefore, long-term follow-up, as with any malignancy, is mandatory. Adequate identification and reporting may well show that this lesion is more common than has been previously thought.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

0020-7292

Print

17

3

Print

null

203-5

J Zerner (J); M E Fenn (ME)

Journal Article (D016428)

null

Adult (UI: D000328, Major: No); Aged (UI: D000368, Major: No); Carcinoma, Basal Cell (UI: D002280, Major: No) - Qualifiers: pathology (UI: Q000473, Major: Yes); surgery (UI: Q000601, Major: No); Female (UI: D005260, Major: No); Humans (UI: D006801, Major: No); Middle Aged (UI: D008875, Major: No); Neoplasm Recurrence, Local (UI: D009364, Major: No); Vulvar Neoplasms (UI: D014846, Major: No) - Qualifiers: pathology (UI: Q000473, Major: Yes); surgery (UI: Q000601, Major: No)

||pathology (1); surgery (0)|||||pathology (1); surgery (0)

0|0|0|0|0|0|0|0

null

1980-03-17

2019-08-19

pubmed: 1979-11-1; medline: 1979-11-1 0:1; entrez: 1979-11-1 0:0

pubmed: 42569; doi: 10.1002/j.1879-3479.1979.tb00150.x

Breast Neoplasms

['Neoplasm Recurrence, Local']

43,008

1

Formaldehyde-fluorescamine-induced fluorescence of mammary carcinoma cells. Lack of concordance with occurrence of oestrogen-binding receptor proteins.

MEDLINE

Manual

NLM

The combined formaldehyde-fluorescamine technique demonstrates fluorescence by mammary carcinoma cells whereas cells of the normal gland or of benign tumours do not show fluorescence. We have studied the correlation between histological staging of the disease, concentrations of oestrogen-binding proteins and the occurrence of formaldehyde-fluorescamine (FF)-inducible fluorescence. Our results demonstrate that the FF-technique detects all types of mammary carcinoma cells irrespective of their concentration of oestrogen receptors. Hence, the FF-technique represents a valuable tool for detecting both hormone-responsive and hormone-unresponsive malignant cells of the mammary gland.

Virchows Archiv. B, Cell pathology including molecular pathology

0340-6075

Print

30

3

Print

1,979

Jun

29

281-7

L Mørch-Jørgensen (L); H S Poulsen (HS); L I Larsson (LI)

Journal Article (D016428)

Neoplasm Proteins (Registry: 0, UI: D009363); Receptors, Estrogen (Registry: 0, UI: D011960); Formaldehyde (Registry: 1HG84L3525, UI: D005557); Fluorescamine (Registry: 38183-12-9, UI: D005450)

Breast Neoplasms (UI: D001943, Major: No) - Qualifiers: analysis (UI: Q000032, Major: No); diagnosis (UI: Q000175, Major: Yes); Female (UI: D005260, Major: No); Fluorescamine (UI: D005450, Major: No); Fluorescence (UI: D005453, Major: Yes); Formaldehyde (UI: D005557, Major: No); Humans (UI: D006801, Major: No); Neoplasm Proteins (UI: D009363, Major: No) - Qualifiers: analysis (UI: Q000032, Major: Yes); Receptors, Estrogen (UI: D011960, Major: No) - Qualifiers: metabolism (UI: Q000378, Major: No)

analysis (0); diagnosis (1)||||||analysis (1)|metabolism (0)

0|0|0|1|0|0|0|0

null

1980-03-24

2019-09-18

pubmed: 1979-6-29; medline: 1979-6-29 0:1; entrez: 1979-6-29 0:0

pubmed: 43008; doi: 10.1007/BF02889108

Breast Neoplasms

[]