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anti-cytokeratin14 ThermoFisherScientific
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Cat#MA5-11599;RRID:AB_10982092
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Elastase Sigma Cat#E1250
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pheatmap(version:1.0.12) N/A
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anti-cytokeratin10 Abcam
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anti-Loricrin Abcam
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anti-ACTA2 Zsbio
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anti-Ki67 Zsbio
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anti-Ki67 Abcam
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anti-PCNA ABclonal
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anti-Nitrotyrosine Millpore
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anti-CPD CosmoBio
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anti-Vimentin ABclonal
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anti-DCT Abcam
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anti-HES1 Abcam
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anti-b-tubulin SantaCruz
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anti-CD207 Abcam
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anti-8-Hydroxydeoxyguanosine MyBioSource
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anti-CYP27A1 Abcam
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anti-COL17A1 Abcam
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anti-SOX9 R&D
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anti-MFAP5 Sigma
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anti-rabbitIgGAlexaFluor488 ThermoFisherScientific
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Cat#A21206; RRID:AB_2535792
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anti-mouseIgGAlexaFluor568
ThermoFisherScientific
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DeoxyribonucleaseI Worthington Cat#LS006333
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RBClysisbuffer BDBiosciences Cat#555899
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7-Amino-ActinomycinD(7-AAD) BDBiosciences Cat#559925
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Crystalviolet BiohaoBiotechnology,China Cat#0502
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Quercetinhydrate TCI Cat#P0042
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L-Ascorbicacid Sigma Cat#A4544-500G
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4%paraformaldehyde,PFA Dingguo,China Cat#AR-0211
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TritonX-100 Sigma-Aldrich Cat#T9284
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RNaseInhibitor ThermoFisherScientific Cat#AM2694
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Promega
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Superasin
Cat#N2615
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ggplot2(version:3.2.1) Wickhametal.,2016
https://ggplot2.tidyverse.org/
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GENIE3(version:1.6.0) Huynh-Thuetal.,2010
https://bioconductor.org/packages/release/bioc/html/ GENIE3.html
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Cytoscape(version:3.7.1) Shannonetal.,2003
https://cytoscape.org/
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CellPhoneDB(version:1.1.0) Vento-Tormoetal.,2018
https://github.com/Teichlab/cellphonedb
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HISAT2(version:2.1.0) Kimetal.,2015
https://ccb.jhu.edu/software/hisat2/index.shtml
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RcisTarget(version:1.4.0) Aibaretal.,2017
https://bioconductor.org/packages/release/bioc/ html/RcisTarget.html
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Loveetal.,2014
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DESeq2(version:1.2.4)
https://bioconductor.org/packages/release/bioc/ html/DESeq2.html
YAML Metadata Warning: empty or missing yaml metadata in repo card (https://huggingface.co/docs/hub/datasets-cards)

A Single-Cell Transcriptomic Atlas of Human Skin Aging

This dataset contains structured tables extracted from the supplementary materials of the publication:

"A single-cell transcriptomic atlas of human skin aging"
Cell Reports, 2020
DOI: 10.1016/j.celrep.2020.108132

The data has been processed from the publication PDF into a .parquet file to facilitate downstream analysis and integration into machine learning workflows.


πŸ“¦ Dataset Description

The dataset includes multiple tables capturing aging-related transcriptomic changes in human skin tissue at the single-cell level. Tables were extracted using PDF parsing tools and contain gene expression summaries and annotations useful for skin biology and aging research.


πŸ”§ Usage Instructions

To load the Parquet file in Python:

import pandas as pd

df = pd.read_parquet("skin_aging_data.parquet")
print(df.head())

πŸš€ Use Cases

  • Aging biomarker discovery in dermal and epidermal compartments
  • Training skin-specific biological age predictors
  • Integrating skin aging profiles with other tissue atlases
  • Cross-species comparison of skin aging signatures
  • Evaluation of anti-aging interventions at single-cell resolution

πŸ“– Citation

If you use this dataset, please cite:

Xie, W., et al. A single-cell transcriptomic atlas of human skin aging. Cell Reports, 2020.
DOI: 10.1016/j.celrep.2020.108132


πŸ™ Acknowledgments

This dataset was curated and converted by Iris Lee for open access machine learning research in aging biology and skin regeneration. ### πŸ§‘β€πŸ’» Team: MultiModalMillenials. Iris Lee (@iris8090)

Source publication by Xie et al. (2020) β€” Cell Reports.

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